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- W2321343372 abstract "Abstract Inorganic pyrophosphate ( PP i) is a key metabolite in cellular bioenergetics under chronic stress conditions in prokaryotes, protists and plants. Inorganic pyrophosphatases ( PP ases) are essential enzymes controlling the cellular concentration of PP i and mediating intracellular pH and Ca 2+ homeostasis. We report the effects of the antimalarial drugs chloroquine ( CQ ) and artemisinin ( ART ) on the in vitro growth of Philasterides dicentrarchi , a scuticociliate parasite of turbot; we also evaluated the action of these drugs on soluble ( sPP ases) and vacuolar H+‐ PP ases (H+‐ PP ases). CQ and ART inhibited the in vitro growth of ciliates with IC 50 values of respectively 74 ± 9 μM and 80 ± 8 μM. CQ inhibits the H+ translocation (with an IC 50 of 13.4 ± 0.2 μM), while ART increased translocation of H+ and acidification. However, both drugs caused a decrease in gene expression of H+‐ PP ases. CQ significantly inhibited the enzymatic activity of sPP ases, decreasing the consumption of intracellular PP i. ART inhibited intracellular accumulation of Ca 2+ induced by ATP , indicating an effect on the Ca 2+ ‐ ATP ase. The results suggest that CQ and ART deregulate enzymes associated with PP i and Ca 2+ metabolism, altering the intracellular pH homeostasis vital for parasite survival and providing a target for the development of new drugs against scuticociliatosis." @default.
- W2321343372 created "2016-06-24" @default.
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- W2321343372 date "2016-02-02" @default.
- W2321343372 modified "2023-09-27" @default.
- W2321343372 title "Enzymes Involved in Pyrophosphate and Calcium Metabolism as Targets for Anti-scuticociliate Chemotherapy" @default.
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- W2321343372 doi "https://doi.org/10.1111/jeu.12294" @default.
- W2321343372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26751587" @default.
- W2321343372 hasPublicationYear "2016" @default.
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