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- W2321457545 abstract "In this cross-sectional study, 53 cervicovaginal lavage samples (CVL) from 41 women were analyzed for the chemokines interleukin-8 (IL-8), regulated-onactivation normal T-expressed and secreted (RANTES) factor, and macrophage inflammatory protein-1α (MIP-1α) by enzyme-linked immunosorbent assay (ELISA). IL-8 was detected in 81% of CVL, whereas RANTES was detected in 32%, and MIP-1α in 15% of the CVL. The mean levels of IL-8, RANTES, and MIP-1α in positive samples were 396 pg/ml, 102 pg/ml, and 34 pg/ml, respectively. IL-8 levels correlated positively with IL-1β and IgG in a subset of CVL samples. RANTES levels correlated positively with complement protein levels. Additionally, the levels of RANTES, but not MIP-1α, reached levels reported in previous studies of the effects of β chemokines to inhibit HIV replication. These results suggest that measuring chemokines in CVL specimens can provide important information regarding immune responses in the genital tract." @default.
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- W2321457545 date "1998-08-01" @default.
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- W2321457545 title "Chemokines Are Present in the Genital Tract of HIV-Seropositive and HIV-Seronegative Women" @default.
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- W2321457545 doi "https://doi.org/10.1097/00042560-199808150-00006" @default.
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