FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321534831> ?p ?o ?g. }

• W2321534831 abstract "The recently published data of Donadio in Critical Care provide convincing evidence that neutrophil gelatinase-associated lipocalin (NGAL), an established key biomarker of acute kidney injury (AKI) in the critically ill, can be effectively removed by renal replacement therapy (RRT) [1]. His findings challenge recent work by Schilder et al. [2] and corroborate our concern regarding the potential removal of NGAL during continuous RRT (CRRT) [3]. NGAL is expected to be eliminated by convection because its molecular weight (MW) lies below the 30-kDa MW cutoff point of “classic” dialysis membranes. Schilder et al. found almost no clearance of NGAL during continuous veno-venous hemofiltration despite using a 40-kDa MW (high) cutoff cellulose triacetate filter [2]. Donadio used the same filter in patients undergoing high-flux maintenance hemodialysis (MHD) but applied an ultrafiltration rate more than twice as high as that of Schilder et al. (8474 versus 3700 ml/h per 100 mm Hg) and a higher sieving coefficient for middle molecules [4]. Moreover, Donadio observed that hemodiafiltration (HDF) largely outperformed high-flux MHD in plasma NGAL removal (52.1 % versus 26.7 % reduction ratio) [4]. This could be explained by a difference in membrane type. Cellulose triacetate filters have very poor adsorption capacity [5]. In contrast, the acrylonitrile (AN) and natrium metallylsulfone copolymer membrane used for MHD in the Donadio study has characteristics similar to those of the highly adsorptive AN69 surface-treated membrane used for CRRT in critically ill patients [5]. As this filter displays a lower MW cutoff than that of cellulose triacetate (30 versus 40 kDa), the remarkable removal of NGAL from plasma in patients undergoing HDF is not explained by increased convection alone but is likely related to additional membrane adsorption.Taken together, the recent work [4] and comments including the additional data [1] of Donadio underscore that NGAL may lose significance to reflect severity and prognosis of AKI in patients receiving RRT because intensified convection or substantial adsorption (or both) on currently used dialysis membranes enhances plasma clearance of this biomarker." @default.
• W2321534831 created "2016-06-24" @default.
• W2321534831 creator A5001137625 @default.
• W2321534831 creator A5011470035 @default.
• W2321534831 date "2016-04-05" @default.
• W2321534831 modified "2023-10-17" @default.
• W2321534831 title "Neutrophil gelatinase-associated lipocalin elimination by renal replacement therapy: minding the membrane!" @default.
• W2321534831 cites W2141202722 @default.
• W2321534831 cites W2146979317 @default.
• W2321534831 cites W2207129875 @default.
• W2321534831 cites W2262061995 @default.
• W2321534831 cites W2318474035 @default.
• W2321534831 doi "https://doi.org/10.1186/s13054-016-1258-9" @default.
• W2321534831 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4820941" @default.
• W2321534831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27044560" @default.
• W2321534831 hasPublicationYear "2016" @default.
• W2321534831 type Work @default.
• W2321534831 sameAs 2321534831 @default.
• W2321534831 citedByCount "2" @default.
• W2321534831 countsByYear W23215348312017 @default.
• W2321534831 countsByYear W23215348312019 @default.
• W2321534831 crossrefType "journal-article" @default.
• W2321534831 hasAuthorship W2321534831A5001137625 @default.
• W2321534831 hasAuthorship W2321534831A5011470035 @default.
• W2321534831 hasBestOaLocation W23215348311 @default.
• W2321534831 hasConcept C126322002 @default.
• W2321534831 hasConcept C126894567 @default.
• W2321534831 hasConcept C177713679 @default.
• W2321534831 hasConcept C20299238 @default.
• W2321534831 hasConcept C2779541074 @default.
• W2321534831 hasConcept C2780472472 @default.
• W2321534831 hasConcept C2909801038 @default.
• W2321534831 hasConcept C71924100 @default.
• W2321534831 hasConceptScore W2321534831C126322002 @default.
• W2321534831 hasConceptScore W2321534831C126894567 @default.
• W2321534831 hasConceptScore W2321534831C177713679 @default.
• W2321534831 hasConceptScore W2321534831C20299238 @default.
• W2321534831 hasConceptScore W2321534831C2779541074 @default.
• W2321534831 hasConceptScore W2321534831C2780472472 @default.
• W2321534831 hasConceptScore W2321534831C2909801038 @default.
• W2321534831 hasConceptScore W2321534831C71924100 @default.
• W2321534831 hasIssue "1" @default.
• W2321534831 hasLocation W23215348311 @default.
• W2321534831 hasLocation W23215348312 @default.
• W2321534831 hasLocation W23215348313 @default.
• W2321534831 hasLocation W23215348314 @default.
• W2321534831 hasOpenAccess W2321534831 @default.
• W2321534831 hasPrimaryLocation W23215348311 @default.
• W2321534831 hasRelatedWork W107728123 @default.
• W2321534831 hasRelatedWork W168259873 @default.
• W2321534831 hasRelatedWork W2037772730 @default.
• W2321534831 hasRelatedWork W2100043910 @default.
• W2321534831 hasRelatedWork W2533526202 @default.
• W2321534831 hasRelatedWork W2611644304 @default.
• W2321534831 hasRelatedWork W2895423644 @default.
• W2321534831 hasRelatedWork W2918643122 @default.
• W2321534831 hasRelatedWork W3040330295 @default.
• W2321534831 hasRelatedWork W4213146875 @default.
• W2321534831 hasVolume "20" @default.
• W2321534831 isParatext "false" @default.
• W2321534831 isRetracted "false" @default.
• W2321534831 magId "2321534831" @default.
• W2321534831 workType "article" @default.