Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321538013> ?p ?o ?g. }
- W2321538013 endingPage "1759" @default.
- W2321538013 startingPage "1751" @default.
- W2321538013 abstract "Metallacarborane moieties have been identified as promising pharmacophores. The pharmaceutical use of such compounds is, however, complicated by their low solubility and tendency to self-assemble in aqueous solution. In this work, we estimated the solubilities of a vast series of metallacarboranes [cobalt bis(dicarbollide) derivatives] in pure water, saline, and saline with human serum albumin as a model of blood plasma. In addition, we determined the octanol–water partition coefficients (Pow) as a lipophilicity descriptor. Pow weakly correlates with the water solubility of metallacarboranes, whereas the ability of HSA to increase the solubility of metallacarboranes correlates well with their Pow values. Because metallacarboranes are known inhibitors of HIV protease, the possible correlation between Pow and the ability to inhibit HIV protease was investigated. Results from this study indicate that interaction of metallacarborane inhibitors with HIV protease is driven by specific binding rather than by promiscuous lipophilic interactions. The most promising candidates for further drug development were identified by ligand lipophilicity efficiency analysis." @default.
- W2321538013 created "2016-06-24" @default.
- W2321538013 creator A5028106597 @default.
- W2321538013 creator A5028273894 @default.
- W2321538013 creator A5034876689 @default.
- W2321538013 creator A5036121129 @default.
- W2321538013 creator A5049570743 @default.
- W2321538013 creator A5056281112 @default.
- W2321538013 creator A5066148294 @default.
- W2321538013 date "2013-04-10" @default.
- W2321538013 modified "2023-10-14" @default.
- W2321538013 title "On the Solubility and Lipophilicity of Metallacarborane Pharmacophores" @default.
- W2321538013 cites W1895070749 @default.
- W2321538013 cites W1942804016 @default.
- W2321538013 cites W1965838160 @default.
- W2321538013 cites W1967950583 @default.
- W2321538013 cites W1976217206 @default.
- W2321538013 cites W1989551761 @default.
- W2321538013 cites W1993930688 @default.
- W2321538013 cites W2004116821 @default.
- W2321538013 cites W2009787697 @default.
- W2321538013 cites W2017654147 @default.
- W2321538013 cites W2017968968 @default.
- W2321538013 cites W2018587140 @default.
- W2321538013 cites W2026041309 @default.
- W2321538013 cites W2030150589 @default.
- W2321538013 cites W2035622829 @default.
- W2321538013 cites W2036323515 @default.
- W2321538013 cites W2040402142 @default.
- W2321538013 cites W2046037596 @default.
- W2321538013 cites W2053090997 @default.
- W2321538013 cites W2058292053 @default.
- W2321538013 cites W2062458432 @default.
- W2321538013 cites W2064736675 @default.
- W2321538013 cites W2066313052 @default.
- W2321538013 cites W2070282416 @default.
- W2321538013 cites W2072162209 @default.
- W2321538013 cites W2072877023 @default.
- W2321538013 cites W2076818980 @default.
- W2321538013 cites W2077971886 @default.
- W2321538013 cites W2080338862 @default.
- W2321538013 cites W2080467735 @default.
- W2321538013 cites W2082332887 @default.
- W2321538013 cites W2087019695 @default.
- W2321538013 cites W2087046754 @default.
- W2321538013 cites W2089214220 @default.
- W2321538013 cites W2090237923 @default.
- W2321538013 cites W2093577667 @default.
- W2321538013 cites W2097559461 @default.
- W2321538013 cites W2098499111 @default.
- W2321538013 cites W2108737219 @default.
- W2321538013 cites W2125746135 @default.
- W2321538013 cites W2135865322 @default.
- W2321538013 cites W2141025463 @default.
- W2321538013 cites W2152827703 @default.
- W2321538013 cites W2157225928 @default.
- W2321538013 cites W2170585441 @default.
- W2321538013 cites W2171405337 @default.
- W2321538013 cites W2191500693 @default.
- W2321538013 cites W2315380494 @default.
- W2321538013 cites W2323516673 @default.
- W2321538013 cites W2490082537 @default.
- W2321538013 cites W2498171112 @default.
- W2321538013 cites W2949252049 @default.
- W2321538013 cites W2949842757 @default.
- W2321538013 cites W4229772442 @default.
- W2321538013 cites W4251269201 @default.
- W2321538013 doi "https://doi.org/10.1021/mp300565z" @default.
- W2321538013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23506420" @default.
- W2321538013 hasPublicationYear "2013" @default.
- W2321538013 type Work @default.
- W2321538013 sameAs 2321538013 @default.
- W2321538013 citedByCount "44" @default.
- W2321538013 countsByYear W23215380132013 @default.
- W2321538013 countsByYear W23215380132014 @default.
- W2321538013 countsByYear W23215380132015 @default.
- W2321538013 countsByYear W23215380132016 @default.
- W2321538013 countsByYear W23215380132017 @default.
- W2321538013 countsByYear W23215380132018 @default.
- W2321538013 countsByYear W23215380132019 @default.
- W2321538013 countsByYear W23215380132020 @default.
- W2321538013 countsByYear W23215380132021 @default.
- W2321538013 countsByYear W23215380132022 @default.
- W2321538013 countsByYear W23215380132023 @default.
- W2321538013 crossrefType "journal-article" @default.
- W2321538013 hasAuthorship W2321538013A5028106597 @default.
- W2321538013 hasAuthorship W2321538013A5028273894 @default.
- W2321538013 hasAuthorship W2321538013A5034876689 @default.
- W2321538013 hasAuthorship W2321538013A5036121129 @default.
- W2321538013 hasAuthorship W2321538013A5049570743 @default.
- W2321538013 hasAuthorship W2321538013A5056281112 @default.
- W2321538013 hasAuthorship W2321538013A5066148294 @default.
- W2321538013 hasConcept C155574463 @default.
- W2321538013 hasConcept C178790620 @default.
- W2321538013 hasConcept C181199279 @default.
- W2321538013 hasConcept C184651966 @default.
- W2321538013 hasConcept C185592680 @default.
- W2321538013 hasConcept C192552737 @default.