FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321541805> ?p ?o ?g. }

• W2321541805 endingPage "e0004541" @default.
• W2321541805 startingPage "e0004541" @default.
• W2321541805 abstract "Mycobacteria of the Mycobacterium tuberculosis complex (MTBC) greatly impact human and animal health worldwide. The mycobacterial life cycle is complex, and the mechanisms resulting in pathogen infection and survival in host cells are not fully understood. Eurasian wild boar (Sus scrofa) are natural reservoir hosts for MTBC and a model for mycobacterial infection and tuberculosis (TB). In the wild boar TB model, mycobacterial infection affects the expression of innate and adaptive immune response genes in mandibular lymph nodes and oropharyngeal tonsils, and biomarkers have been proposed as correlates with resistance to natural infection. However, the mechanisms used by mycobacteria to manipulate host immune response are not fully characterized. Our hypothesis is that the immune system proteins under-represented in infected animals, when compared to uninfected controls, are used by mycobacteria to guarantee pathogen infection and transmission. To address this hypothesis, a comparative proteomics approach was used to compare host response between uninfected (TB-) and M. bovis-infected young (TB+) and adult animals with different infection status [TB lesions localized in the head (TB+) or affecting multiple organs (TB++)]. The results identified host immune system proteins that play an important role in host response to mycobacteria. Calcium binding protein A9, Heme peroxidase, Lactotransferrin, Cathelicidin and Peptidoglycan-recognition protein were under-represented in TB+ animals when compared to uninfected TB- controls, but protein levels were higher as infection progressed in TB++ animals when compared to TB- and/or TB+ adult wild boar. MHCI was the only protein over-represented in TB+ adult wild boar when compared to uninfected TB- controls. The results reported here suggest that M. bovis manipulates host immune response by reducing the production of immune system proteins. However, as infection progresses, wild boar immune response recovers to limit pathogen multiplication and promote survival, facilitating pathogen transmission." @default.
• W2321541805 created "2016-06-24" @default.
• W2321541805 creator A5009622932 @default.
• W2321541805 creator A5023832378 @default.
• W2321541805 creator A5030913954 @default.
• W2321541805 creator A5049324673 @default.
• W2321541805 creator A5055638269 @default.
• W2321541805 creator A5059973854 @default.
• W2321541805 creator A5062438511 @default.
• W2321541805 creator A5069671174 @default.
• W2321541805 creator A5071633045 @default.
• W2321541805 creator A5073523114 @default.
• W2321541805 creator A5082851487 @default.
• W2321541805 date "2016-03-30" @default.
• W2321541805 modified "2023-10-18" @default.
• W2321541805 title "Comparative Proteomics Identifies Host Immune System Proteins Affected by Infection with Mycobacterium bovis" @default.
• W2321541805 cites W1546237671 @default.
• W2321541805 cites W1576770393 @default.
• W2321541805 cites W1647647900 @default.
• W2321541805 cites W1769303475 @default.
• W2321541805 cites W1976575734 @default.
• W2321541805 cites W1990603469 @default.
• W2321541805 cites W1991366673 @default.
• W2321541805 cites W1997036735 @default.
• W2321541805 cites W2004360367 @default.
• W2321541805 cites W2006216962 @default.
• W2321541805 cites W2009776996 @default.
• W2321541805 cites W2020773198 @default.
• W2321541805 cites W2026233736 @default.
• W2321541805 cites W2030472958 @default.
• W2321541805 cites W2032269392 @default.
• W2321541805 cites W2042349371 @default.
• W2321541805 cites W2046986557 @default.
• W2321541805 cites W2051560487 @default.
• W2321541805 cites W2055188808 @default.
• W2321541805 cites W2057237340 @default.
• W2321541805 cites W2066321034 @default.
• W2321541805 cites W2066779911 @default.
• W2321541805 cites W2073737981 @default.
• W2321541805 cites W2074862238 @default.
• W2321541805 cites W2074895720 @default.
• W2321541805 cites W2077399813 @default.
• W2321541805 cites W2095223326 @default.
• W2321541805 cites W2098657207 @default.
• W2321541805 cites W2119542402 @default.
• W2321541805 cites W2126828692 @default.
• W2321541805 cites W2133610914 @default.
• W2321541805 cites W2138462906 @default.
• W2321541805 cites W2141361194 @default.
• W2321541805 cites W2146884352 @default.
• W2321541805 cites W2148982058 @default.
• W2321541805 cites W2163835778 @default.
• W2321541805 cites W2164004262 @default.
• W2321541805 cites W2173566693 @default.
• W2321541805 cites W2193352943 @default.
• W2321541805 cites W2207381010 @default.
• W2321541805 cites W2259646174 @default.
• W2321541805 cites W2322438277 @default.
• W2321541805 doi "https://doi.org/10.1371/journal.pntd.0004541" @default.
• W2321541805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4814110" @default.
• W2321541805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27027307" @default.
• W2321541805 hasPublicationYear "2016" @default.
• W2321541805 type Work @default.
• W2321541805 sameAs 2321541805 @default.
• W2321541805 citedByCount "12" @default.
• W2321541805 countsByYear W23215418052017 @default.
• W2321541805 countsByYear W23215418052018 @default.
• W2321541805 countsByYear W23215418052019 @default.
• W2321541805 countsByYear W23215418052020 @default.
• W2321541805 countsByYear W23215418052021 @default.
• W2321541805 countsByYear W23215418052022 @default.
• W2321541805 countsByYear W23215418052023 @default.
• W2321541805 crossrefType "journal-article" @default.
• W2321541805 hasAuthorship W2321541805A5009622932 @default.
• W2321541805 hasAuthorship W2321541805A5023832378 @default.
• W2321541805 hasAuthorship W2321541805A5030913954 @default.
• W2321541805 hasAuthorship W2321541805A5049324673 @default.
• W2321541805 hasAuthorship W2321541805A5055638269 @default.
• W2321541805 hasAuthorship W2321541805A5059973854 @default.
• W2321541805 hasAuthorship W2321541805A5062438511 @default.
• W2321541805 hasAuthorship W2321541805A5069671174 @default.
• W2321541805 hasAuthorship W2321541805A5071633045 @default.
• W2321541805 hasAuthorship W2321541805A5073523114 @default.
• W2321541805 hasAuthorship W2321541805A5082851487 @default.
• W2321541805 hasBestOaLocation W23215418051 @default.
• W2321541805 hasConcept C136449434 @default.
• W2321541805 hasConcept C142724271 @default.
• W2321541805 hasConcept C159047783 @default.
• W2321541805 hasConcept C18903297 @default.
• W2321541805 hasConcept C193419808 @default.
• W2321541805 hasConcept C203014093 @default.
• W2321541805 hasConcept C2776222705 @default.
• W2321541805 hasConcept C2776460866 @default.
• W2321541805 hasConcept C2777975735 @default.
• W2321541805 hasConcept C2778497218 @default.
• W2321541805 hasConcept C2781069245 @default.
• W2321541805 hasConcept C71924100 @default.
• W2321541805 hasConcept C86803240 @default.

• next