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- W2321541978 abstract "Substance P (SP) has been implicated in the regulation of the cardiovascular system, in neuronal survival and degeneration, in the regulation of respiratory mechanisms, and in salivation. This study investigated the presence and distribution of SP and neurokinin 1 receptor (NK-1R) in oral squamous cell carcinoma and their relationship to proliferation, Using monoclonal antibodies against SP, NK-1R, and Ki-67. Ninety oral squamous cell carcinomas from 73 patients were analyzed. Direct significant associations were observed in SP expression between different tissue levels (p < 0.01), between SP and NK-1R tumor cell membrane expression (p < 0.01), and between SP and NK-1R joint expression in tumor cell cytoplasm. In conclusion, the ubiquitous presence of SP strongly suggests a role for SP/NK-1R complex in tumor development and progression and possibly for NK-1R antagonists in the management of patients with oral cancer. Financial support: CNPq–process number: 14280/2006-8/Banco Santander." @default.
- W2321541978 created "2016-06-24" @default.
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- W2321541978 date "2014-02-01" @default.
- W2321541978 modified "2023-09-25" @default.
- W2321541978 title "Role For SP/NK-1R Complex in Cell Proliferation in Oral Squamous Cell Carcinoma" @default.
- W2321541978 doi "https://doi.org/10.1016/j.oooo.2013.12.249" @default.
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