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- W2321550181 abstract "Epithelial‐mesenchymal transition ( EMT ) is a critical response during cancer cell metastasis. In this study, we provide evidence that uncoordinated 51‐like kinase 2 ( ULK 2) regulates EMT . Induction of autophagy by inhibition of mammalian target of rapamycin complex 1 ( mTORC 1) or by disruption of mTORC 1 by silencing raptor significantly enhanced EMT , however, disruption of mTORC 2 by silencing rictor had no effect. Knockdown of ULK 2 expression significantly induced autophagy, EMT , and migration but suppressed proliferation as well as tumor growth in a xenotransplantation model, whereas silencing of ULK 1 had no effect. Therefore, we suggest that ULK 2 regulates EMT through modulation of autophagy." @default.
- W2321550181 created "2016-06-24" @default.
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- W2321550181 date "2016-04-26" @default.
- W2321550181 modified "2023-10-05" @default.
- W2321550181 title "Uncoordinated 51-like kinase 2 signaling pathway regulates epithelial-mesenchymal transition in A549 lung cancer cells" @default.
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- W2321550181 doi "https://doi.org/10.1002/1873-3468.12172" @default.
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