Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321551727> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2321551727 endingPage "S55" @default.
- W2321551727 startingPage "S54" @default.
- W2321551727 abstract "<h3>Aims</h3> Immunohistochemistry for ERG has been reported to be highly sensitive and specific for the TMPRSS2-ERG fusion onco-gene. This fusion oncogene has been found in 50–70% of prostate cancers in screened populations but rarely to never in benign disease. We sought to assess the sensitivity and specificity of immunohistochemistry for ERG for the diagnosis of prostate carcinoma in an Australian population. <h3>Methods</h3> A TMA was constructed containing material from 283 consecutive prostatic adenocarcinomas from radical prostatectomies. Immunohistochemistry was performed with a mouse monoclonal antibody directed against ERG (clone 9FY Biocare Medical, USA). <h3>Results</h3> ERG staining was positive in 146 adenocarcinomas (51.5%). There was no staining of benign glands (specificity 100%). Commonly high grade PIN (HGPIN) adjacent to adeno-carcinoma showed positive staining, but in only two cases was there positive staining in PIN without there being ERG positive carcinoma present in the same TMA core. <h3>Conclusions</h3> ERG shows a sensitivity of 51.5% and a remarkable specificity of 100% for the diagnosis of prostatic adenocarcinoma versus benign glands. ERG positive PIN is almost always associated with invasive adenocarcinoma in the same core biopsy. Immunohistochemistry for ERG may therefore have significant role in the pathological differential diagnosis of difficult prostate biopsies." @default.
- W2321551727 created "2016-06-24" @default.
- W2321551727 creator A5037367588 @default.
- W2321551727 creator A5059986280 @default.
- W2321551727 creator A5075835022 @default.
- W2321551727 creator A5080976246 @default.
- W2321551727 creator A5083013593 @default.
- W2321551727 date "2012-01-01" @default.
- W2321551727 modified "2023-09-27" @default.
- W2321551727 title "ERG immunostaining is highly specific for prostatic adenocarcinoma" @default.
- W2321551727 doi "https://doi.org/10.1016/s0031-3025(16)32732-5" @default.
- W2321551727 hasPublicationYear "2012" @default.
- W2321551727 type Work @default.
- W2321551727 sameAs 2321551727 @default.
- W2321551727 citedByCount "0" @default.
- W2321551727 crossrefType "journal-article" @default.
- W2321551727 hasAuthorship W2321551727A5037367588 @default.
- W2321551727 hasAuthorship W2321551727A5059986280 @default.
- W2321551727 hasAuthorship W2321551727A5075835022 @default.
- W2321551727 hasAuthorship W2321551727A5080976246 @default.
- W2321551727 hasAuthorship W2321551727A5083013593 @default.
- W2321551727 hasConcept C103796816 @default.
- W2321551727 hasConcept C118487528 @default.
- W2321551727 hasConcept C121608353 @default.
- W2321551727 hasConcept C126322002 @default.
- W2321551727 hasConcept C142724271 @default.
- W2321551727 hasConcept C204232928 @default.
- W2321551727 hasConcept C2775934546 @default.
- W2321551727 hasConcept C2776235491 @default.
- W2321551727 hasConcept C2777546739 @default.
- W2321551727 hasConcept C2778042024 @default.
- W2321551727 hasConcept C2779134260 @default.
- W2321551727 hasConcept C2780827179 @default.
- W2321551727 hasConcept C2781182431 @default.
- W2321551727 hasConcept C3008058167 @default.
- W2321551727 hasConcept C4224716 @default.
- W2321551727 hasConcept C524204448 @default.
- W2321551727 hasConcept C71924100 @default.
- W2321551727 hasConceptScore W2321551727C103796816 @default.
- W2321551727 hasConceptScore W2321551727C118487528 @default.
- W2321551727 hasConceptScore W2321551727C121608353 @default.
- W2321551727 hasConceptScore W2321551727C126322002 @default.
- W2321551727 hasConceptScore W2321551727C142724271 @default.
- W2321551727 hasConceptScore W2321551727C204232928 @default.
- W2321551727 hasConceptScore W2321551727C2775934546 @default.
- W2321551727 hasConceptScore W2321551727C2776235491 @default.
- W2321551727 hasConceptScore W2321551727C2777546739 @default.
- W2321551727 hasConceptScore W2321551727C2778042024 @default.
- W2321551727 hasConceptScore W2321551727C2779134260 @default.
- W2321551727 hasConceptScore W2321551727C2780827179 @default.
- W2321551727 hasConceptScore W2321551727C2781182431 @default.
- W2321551727 hasConceptScore W2321551727C3008058167 @default.
- W2321551727 hasConceptScore W2321551727C4224716 @default.
- W2321551727 hasConceptScore W2321551727C524204448 @default.
- W2321551727 hasConceptScore W2321551727C71924100 @default.
- W2321551727 hasLocation W23215517271 @default.
- W2321551727 hasOpenAccess W2321551727 @default.
- W2321551727 hasPrimaryLocation W23215517271 @default.
- W2321551727 hasRelatedWork W1911855357 @default.
- W2321551727 hasRelatedWork W2044093030 @default.
- W2321551727 hasRelatedWork W2050973520 @default.
- W2321551727 hasRelatedWork W2077549013 @default.
- W2321551727 hasRelatedWork W2082230118 @default.
- W2321551727 hasRelatedWork W2084656721 @default.
- W2321551727 hasRelatedWork W2091288012 @default.
- W2321551727 hasRelatedWork W2147779944 @default.
- W2321551727 hasRelatedWork W2149742514 @default.
- W2321551727 hasRelatedWork W2164896815 @default.
- W2321551727 hasRelatedWork W2353682676 @default.
- W2321551727 hasRelatedWork W2363946610 @default.
- W2321551727 hasRelatedWork W2378301125 @default.
- W2321551727 hasRelatedWork W2441423124 @default.
- W2321551727 hasRelatedWork W2605321527 @default.
- W2321551727 hasRelatedWork W2746501584 @default.
- W2321551727 hasRelatedWork W3006802918 @default.
- W2321551727 hasRelatedWork W3030780487 @default.
- W2321551727 hasRelatedWork W3209025166 @default.
- W2321551727 hasRelatedWork W991097305 @default.
- W2321551727 hasVolume "44" @default.
- W2321551727 isParatext "false" @default.
- W2321551727 isRetracted "false" @default.
- W2321551727 magId "2321551727" @default.
- W2321551727 workType "article" @default.