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- W2321579892 abstract "Results: In response to daidzein treatment, DRG neurons showed a significant increase in total neurite length and in tip number per neuron. The neuritogenic effect of daidzein was significantly hampered by specific blockers for Src, protein kinase C delta (PKCδ) and mitogen-activated protein kinase/extracellular signal-regulated kinase kinases (MEK/ERK), but not by those for estrogen receptor (ER). Moreover, daidzein induced phosphorylation of Src, PKCδ and ERK. The activation of PKCδ by daidzein was attenuated in the presence of a Src kinase inhibitor, and that of ERK by daidzein was diminished in the presence of either a Src or PKCδ inhibitor. Conclusion: Daidzein may stimulate neurite outgrowth of DRG neurons depending on Src kinase, PKCδ and ERK signaling pathway." @default.
- W2321579892 created "2016-06-24" @default.
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- W2321579892 date "2012-01-01" @default.
- W2321579892 modified "2023-09-27" @default.
- W2321579892 title "Methods: Dissociated dorsal root ganglia (DRG) cultures were used to study the signaling mechanism of daidzein- induced neuritogenesis by immunocytochemistry and Western blotting." @default.
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