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• W2321593313 startingPage "1177" @default.
• W2321593313 abstract "Piccolo is one of the components of the active zone at chemical synapses and regulates the transport of synaptic vesicles. The piccolo C2A domain is an important calcium sensor and binds with phosphatidylinositol or synaptotagmin-1. Recently, clinical studies suggested that a single nucleotide polymorphism in the piccolo C2A domain might be a causal risk factor for major depression. To clarify the association of piccolo with depression, we produced a transgenic mouse overexpressing the C2A domain of piccolo, and investigated the behavior of these mice. The mice exhibited depression-like behavior in both forced swim and tail suspension tests, suggesting that piccolo might regulate the depressive behavior." @default.
• W2321593313 created "2016-06-24" @default.
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• W2321593313 date "2010-12-29" @default.
• W2321593313 modified "2023-10-16" @default.
• W2321593313 title "Overexpression of piccolo C2A domain induces depression-like behavior in mice" @default.
• W2321593313 cites W2041028158 @default.
• W2321593313 doi "https://doi.org/10.1097/wnr.0b013e3283411685" @default.
• W2321593313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20980930" @default.
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