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- W2321621265 abstract "Recently the possible roles of interleukin-22 (IL-22) in pathogenesis in various human neoplasms including oral squamous cell carcinoma have been reported. IL-22, a member of the IL-10 family is produced by immune cells such as natural killer (NK) cells, natural killer T (NKT) cells and activated T cells. IL-22 receptor (IL-22R) is expressed in epithelial cells, but is not present in immune cells. IL-22 has important functions in host defense at mucosal surfaces by promoting the production of antimicrobial peptides from epithelial cells. In addition IL-22 mediates keratinocyte proliferation and epidermal hyperplasia, inhibits terminal differentiation of keratinocytes. More than 90% of oral cancer is squamous cell carcinoma and considered that derived from epithelial dysplasia. However, the specific role of IL-22 in epithelial dysplasia especially borderline malignant lesion remains unclear. Therefore, in the present study, we investigated the involvement of IL-22/IL-22R in epithelial dysplasia." @default.
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- W2321621265 date "2014-09-01" @default.
- W2321621265 modified "2023-10-04" @default.
- W2321621265 title "Increased expression of interleukin-22 and its receptor in early oral neoplastic lesions" @default.
- W2321621265 doi "https://doi.org/10.1016/j.joms.2014.06.289" @default.
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