Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321622246> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2321622246 abstract "Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DCα-santalol, a major component of sandalwood oil inhibits growth of cultured prostate cancer cells in vitro by causing apoptosis. The present study was undertaken to determine the in vivo efficacy of α-santalol using TRAMP (Transgenic Adenocarcinoma of Mouse Prostate) mice as a model. The i.p administration of α-santalol (50 mg/kg) did not cause any side effects or weight loss throughout the study. Administration of α-santalol (50 mg/kg) showed a trend in decrease in average wet weights of urogenital weights compared to control mice (∼34% decrease in α-santalol group compared to control). Furthermore, the dorsolateral sections of prostate from α-santalol-treated mice exhibited decreased cell proliferation in association with induction of apoptosis. Western blotting analysis of prostate tumor samples from α-santalol-treated group revealed an increase in the expression levels of cleaved PARP, phospho p53 (ser 15), cleaved caspase-3, cyclin B, p21 and a modest reduction in antiapoptotic protein Bcl-xL compared to control samples. In agreement with these results, α-santalol treatment resulted in G2/M cell cycle arrest in cultured prostate cancer cells. In conclusion, the present study indicates that α-santalol administration inhibits the development of prostate cancer in TRAMP mice by decreasing cell proliferation, causing cell cycle arrest, and inducing apoptosis. This study was supported by Wilkes University Type I grant, American Association of Colleges of Pharmacy and by Translational Cancer Research Center funded by South Dakota Governor's Office of Economic Development.Citation Format: Ajay Bommareddy, William Eggelston, Stacy Prelewicz, Andrea Antal, Adam L. VanWert, Hiral Patel, Aleona Chinikaylo, Linda S. Gutierrez, Santha Sreevidya, Chandradhar Dwivedi. Chemoprevention of prostate carcinogenesis in TRAMP mice by α-santalol by causing cell cycle arrest and induction of apoptosis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3713. doi:10.1158/1538-7445.AM2013-3713" @default.
- W2321622246 created "2016-06-24" @default.
- W2321622246 creator A5003615490 @default.
- W2321622246 creator A5033400358 @default.
- W2321622246 creator A5036106853 @default.
- W2321622246 creator A5037539790 @default.
- W2321622246 creator A5060323521 @default.
- W2321622246 creator A5061287437 @default.
- W2321622246 creator A5068737953 @default.
- W2321622246 creator A5070145180 @default.
- W2321622246 creator A5074541728 @default.
- W2321622246 creator A5084630126 @default.
- W2321622246 date "2013-04-15" @default.
- W2321622246 modified "2023-09-28" @default.
- W2321622246 title "Abstract 3713: Chemoprevention of prostate carcinogenesis in TRAMP mice by α-santalol by causing cell cycle arrest and induction of apoptosis." @default.
- W2321622246 doi "https://doi.org/10.1158/1538-7445.am2013-3713" @default.
- W2321622246 hasPublicationYear "2013" @default.
- W2321622246 type Work @default.
- W2321622246 sameAs 2321622246 @default.
- W2321622246 citedByCount "0" @default.
- W2321622246 crossrefType "proceedings-article" @default.
- W2321622246 hasAuthorship W2321622246A5003615490 @default.
- W2321622246 hasAuthorship W2321622246A5033400358 @default.
- W2321622246 hasAuthorship W2321622246A5036106853 @default.
- W2321622246 hasAuthorship W2321622246A5037539790 @default.
- W2321622246 hasAuthorship W2321622246A5060323521 @default.
- W2321622246 hasAuthorship W2321622246A5061287437 @default.
- W2321622246 hasAuthorship W2321622246A5068737953 @default.
- W2321622246 hasAuthorship W2321622246A5070145180 @default.
- W2321622246 hasAuthorship W2321622246A5074541728 @default.
- W2321622246 hasAuthorship W2321622246A5084630126 @default.
- W2321622246 hasConcept C121608353 @default.
- W2321622246 hasConcept C126322002 @default.
- W2321622246 hasConcept C143998085 @default.
- W2321622246 hasConcept C16685009 @default.
- W2321622246 hasConcept C190283241 @default.
- W2321622246 hasConcept C2776235491 @default.
- W2321622246 hasConcept C2778313021 @default.
- W2321622246 hasConcept C2780192828 @default.
- W2321622246 hasConcept C2780940892 @default.
- W2321622246 hasConcept C502942594 @default.
- W2321622246 hasConcept C55493867 @default.
- W2321622246 hasConcept C555283112 @default.
- W2321622246 hasConcept C61367390 @default.
- W2321622246 hasConcept C71924100 @default.
- W2321622246 hasConcept C86803240 @default.
- W2321622246 hasConceptScore W2321622246C121608353 @default.
- W2321622246 hasConceptScore W2321622246C126322002 @default.
- W2321622246 hasConceptScore W2321622246C143998085 @default.
- W2321622246 hasConceptScore W2321622246C16685009 @default.
- W2321622246 hasConceptScore W2321622246C190283241 @default.
- W2321622246 hasConceptScore W2321622246C2776235491 @default.
- W2321622246 hasConceptScore W2321622246C2778313021 @default.
- W2321622246 hasConceptScore W2321622246C2780192828 @default.
- W2321622246 hasConceptScore W2321622246C2780940892 @default.
- W2321622246 hasConceptScore W2321622246C502942594 @default.
- W2321622246 hasConceptScore W2321622246C55493867 @default.
- W2321622246 hasConceptScore W2321622246C555283112 @default.
- W2321622246 hasConceptScore W2321622246C61367390 @default.
- W2321622246 hasConceptScore W2321622246C71924100 @default.
- W2321622246 hasConceptScore W2321622246C86803240 @default.
- W2321622246 hasLocation W23216222461 @default.
- W2321622246 hasOpenAccess W2321622246 @default.
- W2321622246 hasPrimaryLocation W23216222461 @default.
- W2321622246 hasRelatedWork W1969271264 @default.
- W2321622246 hasRelatedWork W1994117241 @default.
- W2321622246 hasRelatedWork W2000250011 @default.
- W2321622246 hasRelatedWork W2014128084 @default.
- W2321622246 hasRelatedWork W2030367092 @default.
- W2321622246 hasRelatedWork W2057612451 @default.
- W2321622246 hasRelatedWork W2062878761 @default.
- W2321622246 hasRelatedWork W2076383636 @default.
- W2321622246 hasRelatedWork W2084780129 @default.
- W2321622246 hasRelatedWork W2086843525 @default.
- W2321622246 hasRelatedWork W2093563346 @default.
- W2321622246 hasRelatedWork W2178563668 @default.
- W2321622246 hasRelatedWork W2274485809 @default.
- W2321622246 hasRelatedWork W2321788886 @default.
- W2321622246 hasRelatedWork W2356371715 @default.
- W2321622246 hasRelatedWork W2484658642 @default.
- W2321622246 hasRelatedWork W2499870864 @default.
- W2321622246 hasRelatedWork W2561172014 @default.
- W2321622246 hasRelatedWork W2954134624 @default.
- W2321622246 hasRelatedWork W2615644700 @default.
- W2321622246 isParatext "false" @default.
- W2321622246 isRetracted "false" @default.
- W2321622246 magId "2321622246" @default.
- W2321622246 workType "article" @default.