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- W2321636951 abstract "Upregulation of angiotensin II receptor, may be involved in the initiation and progression of atherosclerosis. To examine the contribution of AT1 receptor in the expression of matrix metalloproteinase-1 (MMP-1) and its tissue inhibitor (TIMP-2) in lipid-deposited arterial tissues, New Zealand white rabbits were given high-cholesterol chow (with losartan 25 mg/d or vehicle) for 10 weeks. Losartan reduced the areas of sudanophilia in the aorta of rabbits fed high-cholesterol diet (p < 0.01 vs. control). Losartan also significantly decreased the enhanced mRNA expression of MMP-1 and TIMP-2 in aortas of rabbits with high-cholesterol diet. Losartan-treated rabbits revealed a reduction in immunohistochemical expression of MMP-1, whereas TIMP-2 expression became localized to the intima. In addition, losartan treatment reduced the activation of NF-κB by inhibiting the degradation of its inhibitor Iκ-Bα. These observations demonstrate that AT1 receptor blockade with losartan reduces lipid deposition and exerts potent inhibitory effects on NF-κB activation and modulates the expression of MMP-1 and TIMP-2 in hypercholesterolemic rabbits." @default.
- W2321636951 created "2016-06-24" @default.
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- W2321636951 date "2002-03-01" @default.
- W2321636951 modified "2023-09-27" @default.
- W2321636951 title "Modulation of Matrix Metalloproteinase-1, Its Tissue Inhibitor, and Nuclear Factor-κB by Losartan in Hypercholesterolemic Rabbits" @default.
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- W2321636951 doi "https://doi.org/10.1097/00005344-200203000-00003" @default.
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