Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321678632> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2321678632 endingPage "S42" @default.
- W2321678632 startingPage "S34" @default.
- W2321678632 abstract "Membranes from CHO cell lines expressing D1, D2, D3, and D4 receptors were used to demonstrate preferential affinities of the dopamine (DA) agonists U-91356A and pramipexole to D2 and D3 receptors, respectively; quinpirole bound with approximately equal affinities to D2, D3, and D4 receptors, and apomorphine bound with good affinity to all subtypes. Both pramipexole and U-91356A depressed DA neuronal cell firing in the substantia nigra pars compacta and the ventral tegmental area. Combinations of the two agonists resulted in greater than additive effects, indicating D2-D3 synergism at the somatodendritic autoreceptor level. The D3-selective antagonist U-99194A selectively bound to D3 receptors and more effectively blocked apomorphine and the pramipexole-U-91356A combination than it blocked either compound alone. Type II caudate neurons of anesthetized rats were excited by amphetamine, apomorphine, quinpirole, and pramipexole, the preferential D3 agonist, but not by U-91356A, the preferential D2 agonist. In anesthetized rats, recording electrodes were also placed in the substantia nigra pars reticulata (SNPR), a major output target of the caudate. In the SNPR, amphetamine, apomorphine, and quinpirole excited some neurons and inhibited others. Pramipexole inhibited a subpopulation of SNPR neurons, whereas U-91356A stimulated a subpopulation of SNPR neurons. Similarly, pramipexole stimulated some nucleus accumbens (NA) neurons and inhibited others. In 2-deoxyglucose imaging studies, quinpirole almost totally stimulated responsive areas; however, some inhibitory effects were observed. The effects of pramipexole on energy metabolism were limited to stimulation, whereas the effects of U-91356A were almost totally inhibitory. U-99194A blocked stimulation by amphetamine in cortical areas but not in others. It is concluded that these preferential D2- and D3-receptor agonists synergistically interact at somatodendritic DA autoreceptors and that, at higher doses, they have opposite effects, albeit on separate postsynaptic pathways. The relevance to new approaches for treating schizophrenia and Parkinson's disease is discussed." @default.
- W2321678632 created "2016-06-24" @default.
- W2321678632 creator A5040550965 @default.
- W2321678632 creator A5055362118 @default.
- W2321678632 creator A5086886600 @default.
- W2321678632 date "1995-01-01" @default.
- W2321678632 modified "2023-10-14" @default.
- W2321678632 title "Functional Roles for Dopamine-Receptor Subtypes" @default.
- W2321678632 doi "https://doi.org/10.1097/00002826-199501001-00005" @default.
- W2321678632 hasPublicationYear "1995" @default.
- W2321678632 type Work @default.
- W2321678632 sameAs 2321678632 @default.
- W2321678632 citedByCount "38" @default.
- W2321678632 countsByYear W23216786322014 @default.
- W2321678632 crossrefType "journal-article" @default.
- W2321678632 hasAuthorship W2321678632A5040550965 @default.
- W2321678632 hasAuthorship W2321678632A5055362118 @default.
- W2321678632 hasAuthorship W2321678632A5086886600 @default.
- W2321678632 hasConcept C120069818 @default.
- W2321678632 hasConcept C126322002 @default.
- W2321678632 hasConcept C137183658 @default.
- W2321678632 hasConcept C15744967 @default.
- W2321678632 hasConcept C169760540 @default.
- W2321678632 hasConcept C170493617 @default.
- W2321678632 hasConcept C185592680 @default.
- W2321678632 hasConcept C199596767 @default.
- W2321678632 hasConcept C2777525119 @default.
- W2321678632 hasConcept C2778258207 @default.
- W2321678632 hasConcept C2778296116 @default.
- W2321678632 hasConcept C2778938600 @default.
- W2321678632 hasConcept C2779134260 @default.
- W2321678632 hasConcept C2779734285 @default.
- W2321678632 hasConcept C2779989193 @default.
- W2321678632 hasConcept C2780938664 @default.
- W2321678632 hasConcept C513476851 @default.
- W2321678632 hasConcept C55493867 @default.
- W2321678632 hasConcept C71924100 @default.
- W2321678632 hasConcept C86803240 @default.
- W2321678632 hasConcept C98274493 @default.
- W2321678632 hasConceptScore W2321678632C120069818 @default.
- W2321678632 hasConceptScore W2321678632C126322002 @default.
- W2321678632 hasConceptScore W2321678632C137183658 @default.
- W2321678632 hasConceptScore W2321678632C15744967 @default.
- W2321678632 hasConceptScore W2321678632C169760540 @default.
- W2321678632 hasConceptScore W2321678632C170493617 @default.
- W2321678632 hasConceptScore W2321678632C185592680 @default.
- W2321678632 hasConceptScore W2321678632C199596767 @default.
- W2321678632 hasConceptScore W2321678632C2777525119 @default.
- W2321678632 hasConceptScore W2321678632C2778258207 @default.
- W2321678632 hasConceptScore W2321678632C2778296116 @default.
- W2321678632 hasConceptScore W2321678632C2778938600 @default.
- W2321678632 hasConceptScore W2321678632C2779134260 @default.
- W2321678632 hasConceptScore W2321678632C2779734285 @default.
- W2321678632 hasConceptScore W2321678632C2779989193 @default.
- W2321678632 hasConceptScore W2321678632C2780938664 @default.
- W2321678632 hasConceptScore W2321678632C513476851 @default.
- W2321678632 hasConceptScore W2321678632C55493867 @default.
- W2321678632 hasConceptScore W2321678632C71924100 @default.
- W2321678632 hasConceptScore W2321678632C86803240 @default.
- W2321678632 hasConceptScore W2321678632C98274493 @default.
- W2321678632 hasLocation W23216786321 @default.
- W2321678632 hasOpenAccess W2321678632 @default.
- W2321678632 hasPrimaryLocation W23216786321 @default.
- W2321678632 hasRelatedWork W1480993038 @default.
- W2321678632 hasRelatedWork W1971077835 @default.
- W2321678632 hasRelatedWork W1984515516 @default.
- W2321678632 hasRelatedWork W2024791521 @default.
- W2321678632 hasRelatedWork W2045726405 @default.
- W2321678632 hasRelatedWork W2073362485 @default.
- W2321678632 hasRelatedWork W2141047276 @default.
- W2321678632 hasRelatedWork W2320370116 @default.
- W2321678632 hasRelatedWork W4220916618 @default.
- W2321678632 hasRelatedWork W4249825941 @default.
- W2321678632 hasVolume "18" @default.
- W2321678632 isParatext "false" @default.
- W2321678632 isRetracted "false" @default.
- W2321678632 magId "2321678632" @default.
- W2321678632 workType "article" @default.