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• W2321715596 abstract "Gel electrophoresis staining methodologies documented thus far are largely utilized in a biomolecule context-dependent manner. We report herein the development of a generic, ultrafast, and sensitive multimode fluorescent system for the efficient identification of DNA, RNA, and proteins. Interaction between a positively charged, planar ligand-based coordination complex with partner biomolecule leads to aggregation-induced fluorescence quenching and allows for the image contrast generation within one minute. Alternatively, successive reactions of the biomolecule-loaded gel with cation and ligand, in either order of sequence, provide an equally effective staining efficacy. Image contrast reversal is accomplished through a facile washing or photobleaching procedure. The versatility in the applicable target species and signal generation modes provides a hint at the design of novel staining structures and potentially enables the high-throughput readout of biomolecules." @default.
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• W2321715596 date "2011-12-06" @default.
• W2321715596 modified "2023-10-16" @default.
• W2321715596 title "A Coordination Complex System for Generic, Ultrafast, and Sensitive Multimode Fluorescent Staining of Biomolecules" @default.
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• W2321715596 doi "https://doi.org/10.1021/ic201406b" @default.
• W2321715596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22145885" @default.
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