Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321742004> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2321742004 endingPage "90" @default.
- W2321742004 startingPage "283" @default.
- W2321742004 abstract "The nuclear lamina is the karyoskeletal structure, intimately associated with the nuclear envelope, that is widespread among the diverse types of eukaryotic cells. A family of proteins, termed lamins, has been shown to be a prominent component of this lamina, and various members of this family are differentially expressed in different cell types. In mammals, three major lamins (A, B, C) have been identified, and in all cells so far examined lamin B is constitutively expressed while lamins A and C are not, suggesting that lamin B is sufficient to form a functional lamina. Because of this key importance of lamin B, cDNA clones encoding mammalian lamin B were isolated by screening murine cDNA libraries, representing F9 teratocarcinoma cells and fetal liver, with the corresponding cDNA probe of lamin LI of Xenopus laevis. The nucleotide sequence of the murine lamin B mRNA (approximately 2.9 kb) was determined. The deduced amino acid sequence of the encoded polypeptide (587 amino acids; mol. wt. 66760) is highly homologous to X. laevis lamin LI (72.9% identical residues) but displays lower similarity to A-type lamins (53.8% identical amino acid residues with human lamin A). Lamin B also conforms to the general molecular organization principle of the members of the intermediate filament (IF) protein family, i.e., an extended alpha-helical rod domain that is interrupted by two non alpha-helical linkers and flanked by non-alpha-helical head (amino-terminal) and tail (carboxy-terminal) domains. The tail domain, which does not reveal a hydrophobic region of considerable length, contains a typical karyophilic signal sequence and an uninterrupted stretch of eight negatively charged amino acids.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2321742004 created "2016-06-24" @default.
- W2321742004 creator A5027929605 @default.
- W2321742004 creator A5053053716 @default.
- W2321742004 creator A5078191775 @default.
- W2321742004 date "1988-12-01" @default.
- W2321742004 modified "2023-10-01" @default.
- W2321742004 title "Amino acid sequence and molecular characterization of murine lamin B as deduced from cDNA clones." @default.
- W2321742004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3243285" @default.
- W2321742004 hasPublicationYear "1988" @default.
- W2321742004 type Work @default.
- W2321742004 sameAs 2321742004 @default.
- W2321742004 citedByCount "50" @default.
- W2321742004 countsByYear W23217420042013 @default.
- W2321742004 countsByYear W23217420042015 @default.
- W2321742004 countsByYear W23217420042017 @default.
- W2321742004 countsByYear W23217420042018 @default.
- W2321742004 countsByYear W23217420042021 @default.
- W2321742004 countsByYear W23217420042023 @default.
- W2321742004 crossrefType "journal-article" @default.
- W2321742004 hasAuthorship W2321742004A5027929605 @default.
- W2321742004 hasAuthorship W2321742004A5053053716 @default.
- W2321742004 hasAuthorship W2321742004A5078191775 @default.
- W2321742004 hasConcept C104317684 @default.
- W2321742004 hasConcept C142669718 @default.
- W2321742004 hasConcept C1491633281 @default.
- W2321742004 hasConcept C153911025 @default.
- W2321742004 hasConcept C167625842 @default.
- W2321742004 hasConcept C179093185 @default.
- W2321742004 hasConcept C187882448 @default.
- W2321742004 hasConcept C189482833 @default.
- W2321742004 hasConcept C2779535977 @default.
- W2321742004 hasConcept C29512474 @default.
- W2321742004 hasConcept C515207424 @default.
- W2321742004 hasConcept C54355233 @default.
- W2321742004 hasConcept C55493867 @default.
- W2321742004 hasConcept C78383274 @default.
- W2321742004 hasConcept C86339819 @default.
- W2321742004 hasConcept C86803240 @default.
- W2321742004 hasConcept C92825506 @default.
- W2321742004 hasConcept C94912109 @default.
- W2321742004 hasConceptScore W2321742004C104317684 @default.
- W2321742004 hasConceptScore W2321742004C142669718 @default.
- W2321742004 hasConceptScore W2321742004C1491633281 @default.
- W2321742004 hasConceptScore W2321742004C153911025 @default.
- W2321742004 hasConceptScore W2321742004C167625842 @default.
- W2321742004 hasConceptScore W2321742004C179093185 @default.
- W2321742004 hasConceptScore W2321742004C187882448 @default.
- W2321742004 hasConceptScore W2321742004C189482833 @default.
- W2321742004 hasConceptScore W2321742004C2779535977 @default.
- W2321742004 hasConceptScore W2321742004C29512474 @default.
- W2321742004 hasConceptScore W2321742004C515207424 @default.
- W2321742004 hasConceptScore W2321742004C54355233 @default.
- W2321742004 hasConceptScore W2321742004C55493867 @default.
- W2321742004 hasConceptScore W2321742004C78383274 @default.
- W2321742004 hasConceptScore W2321742004C86339819 @default.
- W2321742004 hasConceptScore W2321742004C86803240 @default.
- W2321742004 hasConceptScore W2321742004C92825506 @default.
- W2321742004 hasConceptScore W2321742004C94912109 @default.
- W2321742004 hasIssue "2" @default.
- W2321742004 hasLocation W23217420041 @default.
- W2321742004 hasOpenAccess W2321742004 @default.
- W2321742004 hasPrimaryLocation W23217420041 @default.
- W2321742004 hasRelatedWork W1745698293 @default.
- W2321742004 hasRelatedWork W1978705807 @default.
- W2321742004 hasRelatedWork W1988023403 @default.
- W2321742004 hasRelatedWork W2002404299 @default.
- W2321742004 hasRelatedWork W2012986142 @default.
- W2321742004 hasRelatedWork W2018818407 @default.
- W2321742004 hasRelatedWork W2042715886 @default.
- W2321742004 hasRelatedWork W2068048912 @default.
- W2321742004 hasRelatedWork W2141409053 @default.
- W2321742004 hasRelatedWork W2321742004 @default.
- W2321742004 hasVolume "47" @default.
- W2321742004 isParatext "false" @default.
- W2321742004 isRetracted "false" @default.
- W2321742004 magId "2321742004" @default.
- W2321742004 workType "article" @default.