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• W2321744016 abstract "Event Abstract Back to Event Background of Primary Immunodeficiencies in the Patients with Severe Atopic Dermatitis Babak Torabi Sagvand1, Asghar Aghamohammadi1*, Hassan Abolhassani1*, Zahra Gholizadeh Moghaddam1, Zahra Hallaji2, Hossein Mortazavi2 and Payam Mohammadinejad1 1 Tehran University of Medical Science, Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Iran 2 Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Iran Primary immunodeficiency diseases (PIDs) are a group of heterogeneous inherited disorders, characterized by recurrent infections, autoimmunity and malignancy. Some PIDs such as hyper IgE syndrome (HIES) and Wiskott-Aldrich syndrome (WAS) may be initially presented as atopic dermatisis (AD), especially in its severe form resulting in diagnostic delay and poor prognosis of patients. The aim of this study was to evaluate the frequency of PIDs among patients with severe AD and to determine factors that can help to raise suspicion toward these disorders. Seventy-five patients with a well-established diagnosis of severe AD were enrolled in this study. Initial immunological evaluations, including humoral and cellular investigation were performed in all individuals. Patients underwent further investigations in a case of suspicious to a probable PID. Among all patients with severe AD, 5 (6.6%) were diagnosed with HIES and 1 (1.3%) with WAS. Family history of PIDs, family history of death in early infancy, positive history of recurrent infections such as skin and respiratory infections, otitis media and sinusitis were observed significantly higher in patients with a diagnosis of PID. The presence of an underlying PID could explain the poor prognosis and refraction to treatment of some patients with severe AD. Several clinical and laboratory findings can help the physicians to focus toward PIDs which are more serious. Delay in diagnosis of PID cases with skin manifestation of AD without proper management may results in lower quality of life and higher morbidity and mortality rates. Keywords: atopic dermatitis, Wiskott-Aldrich Syndrome, Hyper IgE syndrome, history of recurrent infections, cutaneous complication Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune-mediated disease pathogenesis Citation: Torabi Sagvand B, Aghamohammadi A, Abolhassani H, Gholizadeh Moghaddam Z, Hallaji Z, Mortazavi H and Mohammadinejad P (2013). Background of Primary Immunodeficiencies in the Patients with Severe Atopic Dermatitis. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00322 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 16 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Prof. Asghar Aghamohammadi, Tehran University of Medical Science, Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran, Iran, aghamohammadi@tums.ac.ir Dr. Hassan Abolhassani, Tehran University of Medical Science, Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran, Iran, hassan.abolhassani@ki.se Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Babak Torabi Sagvand Asghar Aghamohammadi Hassan Abolhassani Zahra Gholizadeh Moghaddam Zahra Hallaji Hossein Mortazavi Payam Mohammadinejad Google Babak Torabi Sagvand Asghar Aghamohammadi Hassan Abolhassani Zahra Gholizadeh Moghaddam Zahra Hallaji Hossein Mortazavi Payam Mohammadinejad Google Scholar Babak Torabi Sagvand Asghar Aghamohammadi Hassan Abolhassani Zahra Gholizadeh Moghaddam Zahra Hallaji Hossein Mortazavi Payam Mohammadinejad PubMed Babak Torabi Sagvand Asghar Aghamohammadi Hassan Abolhassani Zahra Gholizadeh Moghaddam Zahra Hallaji Hossein Mortazavi Payam Mohammadinejad Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2321744016 title "Background of Primary Immunodeficiencies in the Patients with Severe Atopic Dermatitis" @default.
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