Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321762004> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2321762004 endingPage "3" @default.
- W2321762004 startingPage "3" @default.
- W2321762004 abstract "Cyelin, or Proliferating cell nuclear antigen (PCNA) is a cell cycle related nuclear protein expressed in increased levels during the late Gl and S phases of DNA synthesis. Previous workers have correlated the degree of PCNA positivity with grade and mitotic activity in solid carcinomas, particularly carcinoma of the breast and colon. We attempted to correlate the degree of PCNA activity in malignant, borderline and benign epithelial tumours of the ovary with a view to determining if this might prove useful in categorising these lesions. A total of 51 cases serous and mucinous ovarian tumours diagnosed in our department were studied. These comprised 17 serous (benign = 5; borderline=5; malignant=7) and 34 mucinous (benign = 5; borderline=15; malignant=14) tumours. All lesions were reviewed histologically, typed and graded according to established criteria. PCNA expression was determined using a standard PAP technique described previously. Slides were evaluated for PCNA positivity at a magnification of X 160. The percentage positivity was derived by counting at least 1000 epithelial cells in each case studied. PCNA positivity was significantly higher in malignant tumours of ovary (<mml:math><mml:mrow>X<mml:mo>¯</mml:mo></mml:mrow></mml:math>=27.7%) when compared with borderline (<mml:math><mml:mrow>X<mml:mo>¯</mml:mo></mml:mrow></mml:math>=2.2%) and benign (<mml:math><mml:mrow>X<mml:mo>¯</mml:mo></mml:mrow></mml:math>=1.0%) tumours. The results show that PCNA activity is a useful criterion in differentiating between borderline and malignant epithelial tumours of the ovary, especially in instances when the histological diagnosis is equivocal." @default.
- W2321762004 created "2016-06-24" @default.
- W2321762004 creator A5076110019 @default.
- W2321762004 creator A5082708152 @default.
- W2321762004 date "1993-01-01" @default.
- W2321762004 modified "2023-09-27" @default.
- W2321762004 title "Study of PCNA / cyclin expression in benign, borderline & malignant epithelial tumours of ovary" @default.
- W2321762004 doi "https://doi.org/10.1016/s0031-3025(16)35721-x" @default.
- W2321762004 hasPublicationYear "1993" @default.
- W2321762004 type Work @default.
- W2321762004 sameAs 2321762004 @default.
- W2321762004 citedByCount "0" @default.
- W2321762004 crossrefType "journal-article" @default.
- W2321762004 hasAuthorship W2321762004A5076110019 @default.
- W2321762004 hasAuthorship W2321762004A5082708152 @default.
- W2321762004 hasConcept C134018914 @default.
- W2321762004 hasConcept C142724271 @default.
- W2321762004 hasConcept C150173356 @default.
- W2321762004 hasConcept C204232928 @default.
- W2321762004 hasConcept C2777546739 @default.
- W2321762004 hasConcept C2778324911 @default.
- W2321762004 hasConcept C34688535 @default.
- W2321762004 hasConcept C71924100 @default.
- W2321762004 hasConcept C86803240 @default.
- W2321762004 hasConceptScore W2321762004C134018914 @default.
- W2321762004 hasConceptScore W2321762004C142724271 @default.
- W2321762004 hasConceptScore W2321762004C150173356 @default.
- W2321762004 hasConceptScore W2321762004C204232928 @default.
- W2321762004 hasConceptScore W2321762004C2777546739 @default.
- W2321762004 hasConceptScore W2321762004C2778324911 @default.
- W2321762004 hasConceptScore W2321762004C34688535 @default.
- W2321762004 hasConceptScore W2321762004C71924100 @default.
- W2321762004 hasConceptScore W2321762004C86803240 @default.
- W2321762004 hasLocation W23217620041 @default.
- W2321762004 hasOpenAccess W2321762004 @default.
- W2321762004 hasPrimaryLocation W23217620041 @default.
- W2321762004 hasRelatedWork W1993718294 @default.
- W2321762004 hasRelatedWork W2001529237 @default.
- W2321762004 hasRelatedWork W2021786230 @default.
- W2321762004 hasRelatedWork W2033610296 @default.
- W2321762004 hasRelatedWork W2102786229 @default.
- W2321762004 hasRelatedWork W2129040990 @default.
- W2321762004 hasRelatedWork W2143076108 @default.
- W2321762004 hasRelatedWork W2315279391 @default.
- W2321762004 hasRelatedWork W2361498127 @default.
- W2321762004 hasRelatedWork W2367091415 @default.
- W2321762004 hasRelatedWork W2376650873 @default.
- W2321762004 hasRelatedWork W2389622126 @default.
- W2321762004 hasRelatedWork W2405409618 @default.
- W2321762004 hasRelatedWork W2409675018 @default.
- W2321762004 hasRelatedWork W2438130595 @default.
- W2321762004 hasRelatedWork W2460079111 @default.
- W2321762004 hasRelatedWork W2899708102 @default.
- W2321762004 hasRelatedWork W2947073664 @default.
- W2321762004 hasRelatedWork W2996157840 @default.
- W2321762004 hasRelatedWork W3213279817 @default.
- W2321762004 hasVolume "25" @default.
- W2321762004 isParatext "false" @default.
- W2321762004 isRetracted "false" @default.
- W2321762004 magId "2321762004" @default.
- W2321762004 workType "article" @default.