FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321762212> ?p ?o ?g. }

• W2321762212 endingPage "703" @default.
• W2321762212 startingPage "695" @default.
• W2321762212 abstract "We examined the effects of the calcium channel blockers nitrendipine, diltiazem, verapamil, bepridil, and mibefradil on the cloned HERG and KvLQT1/IsK K+ channels. These channels generate the rapid and slow components of the cardiac delayed rectifier K+ current, and mutations can affect them, which leads to long QT syndromes. When expressed in transfected COS cells, HERG is blocked in a concentration-dependent manner by bepridil (EC50 = 0.55 microM), verapamil (EC50 = 0.83 microM), and mibefradil (EC50 = 1.43 microM), whereas nitrendipine and diltiazem have negligible effects. Steady state activation and inactivation parameters are shifted to more negative values in the presence of the blockers. Similarly, KvLQT1/IsK is inhibited by bepridil (EC50 = 10.0 microM) and mibefradil (EC50 = 11.8 microM), while being insensitive to nitrendipine, diltiazem, or verapamil. These results demonstrate that both cloned K+ channels HERG and KvLQT1/IsK, which represent together the cardiac delayed rectifier K+ current, are sensitive targets to calcium channel blockers. This work may help in understanding the mechanisms of action of verapamil in certain ventricular tachycardia, as well as some of the deleterious adverse cardiac events associated with bepridil." @default.
• W2321762212 created "2016-06-24" @default.
• W2321762212 creator A5010278159 @default.
• W2321762212 creator A5013230246 @default.
• W2321762212 creator A5041668518 @default.
• W2321762212 creator A5062213704 @default.
• W2321762212 creator A5068045779 @default.
• W2321762212 date "1998-10-01" @default.
• W2321762212 modified "2023-09-23" @default.
• W2321762212 title "HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers." @default.
• W2321762212 cites W1968098810 @default.
• W2321762212 cites W1972487161 @default.
• W2321762212 cites W1975869151 @default.
• W2321762212 cites W1979924020 @default.
• W2321762212 cites W1983137097 @default.
• W2321762212 cites W1985715879 @default.
• W2321762212 cites W1993518586 @default.
• W2321762212 cites W2000751184 @default.
• W2321762212 cites W2002422701 @default.
• W2321762212 cites W2006094057 @default.
• W2321762212 cites W2006501433 @default.
• W2321762212 cites W2009667219 @default.
• W2321762212 cites W2018409817 @default.
• W2321762212 cites W2022766670 @default.
• W2321762212 cites W2069882868 @default.
• W2321762212 cites W2071956483 @default.
• W2321762212 cites W2073396391 @default.
• W2321762212 cites W2076862565 @default.
• W2321762212 cites W2078659551 @default.
• W2321762212 cites W2095192512 @default.
• W2321762212 cites W2098468977 @default.
• W2321762212 cites W2116825577 @default.
• W2321762212 cites W2122508506 @default.
• W2321762212 cites W2143518969 @default.
• W2321762212 cites W2153563850 @default.
• W2321762212 cites W2170201048 @default.
• W2321762212 cites W2171292898 @default.
• W2321762212 cites W2266927133 @default.
• W2321762212 cites W2303396378 @default.
• W2321762212 cites W2305074982 @default.
• W2321762212 cites W2306569625 @default.
• W2321762212 cites W2398902999 @default.
• W2321762212 cites W2400979833 @default.
• W2321762212 cites W2407931818 @default.
• W2321762212 cites W2408333624 @default.
• W2321762212 cites W2410308392 @default.
• W2321762212 cites W2437853605 @default.
• W2321762212 cites W2614168425 @default.
• W2321762212 cites W2727581825 @default.
• W2321762212 cites W2898897524 @default.
• W2321762212 cites W2263092743 @default.
• W2321762212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9765513" @default.
• W2321762212 hasPublicationYear "1998" @default.
• W2321762212 type Work @default.
• W2321762212 sameAs 2321762212 @default.
• W2321762212 citedByCount "46" @default.
• W2321762212 countsByYear W23217622122012 @default.
• W2321762212 countsByYear W23217622122013 @default.
• W2321762212 countsByYear W23217622122014 @default.
• W2321762212 countsByYear W23217622122015 @default.
• W2321762212 countsByYear W23217622122017 @default.
• W2321762212 countsByYear W23217622122022 @default.
• W2321762212 crossrefType "journal-article" @default.
• W2321762212 hasAuthorship W2321762212A5010278159 @default.
• W2321762212 hasAuthorship W2321762212A5013230246 @default.
• W2321762212 hasAuthorship W2321762212A5041668518 @default.
• W2321762212 hasAuthorship W2321762212A5062213704 @default.
• W2321762212 hasAuthorship W2321762212A5068045779 @default.
• W2321762212 hasConcept C126322002 @default.
• W2321762212 hasConcept C153461711 @default.
• W2321762212 hasConcept C185592680 @default.
• W2321762212 hasConcept C2776066529 @default.
• W2321762212 hasConcept C2776741139 @default.
• W2321762212 hasConcept C2777022698 @default.
• W2321762212 hasConcept C2778673320 @default.
• W2321762212 hasConcept C2778937662 @default.
• W2321762212 hasConcept C2779362680 @default.
• W2321762212 hasConcept C2780548744 @default.
• W2321762212 hasConcept C2781212610 @default.
• W2321762212 hasConcept C519063684 @default.
• W2321762212 hasConcept C71924100 @default.
• W2321762212 hasConcept C83743174 @default.
• W2321762212 hasConcept C85520022 @default.
• W2321762212 hasConcept C98274493 @default.
• W2321762212 hasConceptScore W2321762212C126322002 @default.
• W2321762212 hasConceptScore W2321762212C153461711 @default.
• W2321762212 hasConceptScore W2321762212C185592680 @default.
• W2321762212 hasConceptScore W2321762212C2776066529 @default.
• W2321762212 hasConceptScore W2321762212C2776741139 @default.
• W2321762212 hasConceptScore W2321762212C2777022698 @default.
• W2321762212 hasConceptScore W2321762212C2778673320 @default.
• W2321762212 hasConceptScore W2321762212C2778937662 @default.
• W2321762212 hasConceptScore W2321762212C2779362680 @default.
• W2321762212 hasConceptScore W2321762212C2780548744 @default.
• W2321762212 hasConceptScore W2321762212C2781212610 @default.
• W2321762212 hasConceptScore W2321762212C519063684 @default.
• W2321762212 hasConceptScore W2321762212C71924100 @default.
• W2321762212 hasConceptScore W2321762212C83743174 @default.

• next