FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321771270> ?p ?o ?g. }

• W2321771270 endingPage "520" @default.
• W2321771270 startingPage "517" @default.
• W2321771270 abstract "Various agonist-induced cell responses in neutrophils and fibroblasts, such as chemotaxis and cytoskeletal rearrangements, have been shown to correlate with the synthesis of PtdIns(3,4,5)P3; however, the significance of this rise in second messenger levels is not clear. We show here that wortmannin inhibits platelet-derived growth factor (PDGF)-mediated production of PtdIns(3,4,5)P3 in human foreskin fibroblasts with an IC50 of about 5 nM. A similar inhibition was observed in in vitro assays (IC50 approximately 1 nM) with phosphatidylinositol 3-kinase immunoprecipitated by antibodies directed against the 85 kDa subunit (p85). On the other hand, wortmannin did not affect PDGF-mediated phosphorylation of p85 as detected by immunoprecipitation with anti-phosphotyrosine antibodies, and did not dissociate the complex of p85 and the catalytic subunit (p110) of phosphatidylinositol 3-kinase. These results are consistent with a direct, specific inhibition of the enzyme by wortmannin at concentrations relevant for its previously reported effects on cellular responses. When stimulated with PDGF, human foreskin fibroblasts form circular structures of filamentous actin. Preincubation of these cells with wortmannin inhibits PDGF-mediated actin rearrangements, suggesting a need for PtdIns(3,4,5)P3 formation as a signal for this cell response." @default.
• W2321771270 created "2016-06-24" @default.
• W2321771270 creator A5022080003 @default.
• W2321771270 creator A5037844122 @default.
• W2321771270 date "1994-03-15" @default.
• W2321771270 modified "2023-09-26" @default.
• W2321771270 title "Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts" @default.
• W2321771270 cites W1502982513 @default.
• W2321771270 cites W1548377812 @default.
• W2321771270 cites W1550035003 @default.
• W2321771270 cites W1550680550 @default.
• W2321771270 cites W1570590300 @default.
• W2321771270 cites W1583256888 @default.
• W2321771270 cites W1599492027 @default.
• W2321771270 cites W1608344832 @default.
• W2321771270 cites W1631080589 @default.
• W2321771270 cites W1768606565 @default.
• W2321771270 cites W1818313483 @default.
• W2321771270 cites W1920844816 @default.
• W2321771270 cites W1964774404 @default.
• W2321771270 cites W1970575648 @default.
• W2321771270 cites W1975638311 @default.
• W2321771270 cites W1975642651 @default.
• W2321771270 cites W1983344122 @default.
• W2321771270 cites W2005529016 @default.
• W2321771270 cites W2010234097 @default.
• W2321771270 cites W2039978832 @default.
• W2321771270 cites W2041102071 @default.
• W2321771270 cites W2050759207 @default.
• W2321771270 cites W2053907246 @default.
• W2321771270 cites W2074571771 @default.
• W2321771270 cites W2091659591 @default.
• W2321771270 cites W2102431039 @default.
• W2321771270 cites W2103043702 @default.
• W2321771270 cites W2105490477 @default.
• W2321771270 cites W2157189324 @default.
• W2321771270 cites W2161316513 @default.
• W2321771270 cites W2185959026 @default.
• W2321771270 cites W2368817160 @default.
• W2321771270 cites W350157235 @default.
• W2321771270 doi "https://doi.org/10.1042/bj2980517" @default.
• W2321771270 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1137889" @default.
• W2321771270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8141762" @default.
• W2321771270 hasPublicationYear "1994" @default.
• W2321771270 type Work @default.
• W2321771270 sameAs 2321771270 @default.
• W2321771270 citedByCount "129" @default.
• W2321771270 countsByYear W23217712702012 @default.
• W2321771270 countsByYear W23217712702013 @default.
• W2321771270 countsByYear W23217712702014 @default.
• W2321771270 countsByYear W23217712702015 @default.
• W2321771270 countsByYear W23217712702017 @default.
• W2321771270 countsByYear W23217712702018 @default.
• W2321771270 countsByYear W23217712702019 @default.
• W2321771270 countsByYear W23217712702021 @default.
• W2321771270 countsByYear W23217712702022 @default.
• W2321771270 crossrefType "journal-article" @default.
• W2321771270 hasAuthorship W2321771270A5022080003 @default.
• W2321771270 hasAuthorship W2321771270A5037844122 @default.
• W2321771270 hasBestOaLocation W23217712702 @default.
• W2321771270 hasConcept C104317684 @default.
• W2321771270 hasConcept C142669718 @default.
• W2321771270 hasConcept C1491633281 @default.
• W2321771270 hasConcept C153911025 @default.
• W2321771270 hasConcept C170493617 @default.
• W2321771270 hasConcept C180361614 @default.
• W2321771270 hasConcept C184235292 @default.
• W2321771270 hasConcept C2775960820 @default.
• W2321771270 hasConcept C2778308172 @default.
• W2321771270 hasConcept C2780610907 @default.
• W2321771270 hasConcept C55493867 @default.
• W2321771270 hasConcept C62478195 @default.
• W2321771270 hasConcept C71829478 @default.
• W2321771270 hasConcept C86803240 @default.
• W2321771270 hasConcept C95444343 @default.
• W2321771270 hasConceptScore W2321771270C104317684 @default.
• W2321771270 hasConceptScore W2321771270C142669718 @default.
• W2321771270 hasConceptScore W2321771270C1491633281 @default.
• W2321771270 hasConceptScore W2321771270C153911025 @default.
• W2321771270 hasConceptScore W2321771270C170493617 @default.
• W2321771270 hasConceptScore W2321771270C180361614 @default.
• W2321771270 hasConceptScore W2321771270C184235292 @default.
• W2321771270 hasConceptScore W2321771270C2775960820 @default.
• W2321771270 hasConceptScore W2321771270C2778308172 @default.
• W2321771270 hasConceptScore W2321771270C2780610907 @default.
• W2321771270 hasConceptScore W2321771270C55493867 @default.
• W2321771270 hasConceptScore W2321771270C62478195 @default.
• W2321771270 hasConceptScore W2321771270C71829478 @default.
• W2321771270 hasConceptScore W2321771270C86803240 @default.
• W2321771270 hasConceptScore W2321771270C95444343 @default.
• W2321771270 hasIssue "3" @default.
• W2321771270 hasLocation W23217712701 @default.
• W2321771270 hasLocation W23217712702 @default.
• W2321771270 hasLocation W23217712703 @default.
• W2321771270 hasLocation W23217712704 @default.
• W2321771270 hasOpenAccess W2321771270 @default.
• W2321771270 hasPrimaryLocation W23217712701 @default.
• W2321771270 hasRelatedWork W1976127908 @default.

• next