Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321793958> ?p ?o ?g. }
- W2321793958 endingPage "303" @default.
- W2321793958 startingPage "298" @default.
- W2321793958 abstract "Purpose of review Ischemia–reperfusion injury is inevitable during intestinal transplantation and can negatively affect the transplant outcome. Here, an overview is provided of the recent advances in the pathophysiological mechanisms of intestinal ischemia–reperfusion injury and how this may impact graft survival. Recent findings The intestine hosts a wide range of microorganisms and its mucosa is heavily populated by immune cells. Intestinal ischemia–reperfusion results in the disruption of the epithelial lining, affecting also protective Paneth cells (antimicrobials) and goblet cells (mucus), and creates a more hostile intraluminal microenvironment. Consequently, both damage-associated molecular patterns as well as pathogen-associated molecular patterns are released from injured tissue and exogenous microorganisms, respectively. These ‘danger’ signals may synergistically activate the innate immune system. Exaggerated innate immune responses, involving neutrophils, mast cells, platelets, dendritic cells, as well as Toll-like receptors and complement proteins, may shape the adaptive T-cell response, thereby triggering the destructive alloimmune response toward the graft and resulting in transplant rejection. Summary Innate immune activation as a consequence of ischemia–reperfusion injury may compromise engraftment of the intestine. More dedicated research is required to further establish this concept in man and to design more effective therapeutic strategies to better tolerize intestinal grafts." @default.
- W2321793958 created "2016-06-24" @default.
- W2321793958 creator A5000883920 @default.
- W2321793958 creator A5019509998 @default.
- W2321793958 creator A5027604191 @default.
- W2321793958 creator A5041852736 @default.
- W2321793958 creator A5056788680 @default.
- W2321793958 creator A5071970006 @default.
- W2321793958 date "2013-06-01" @default.
- W2321793958 modified "2023-10-03" @default.
- W2321793958 title "New insights in intestinal ischemia–reperfusion injury" @default.
- W2321793958 cites W1542578551 @default.
- W2321793958 cites W1550722396 @default.
- W2321793958 cites W1593435431 @default.
- W2321793958 cites W1599953786 @default.
- W2321793958 cites W1972157068 @default.
- W2321793958 cites W1972469797 @default.
- W2321793958 cites W1973472320 @default.
- W2321793958 cites W1978029768 @default.
- W2321793958 cites W1985672713 @default.
- W2321793958 cites W1985807312 @default.
- W2321793958 cites W1994049692 @default.
- W2321793958 cites W1994385249 @default.
- W2321793958 cites W1997472755 @default.
- W2321793958 cites W2003212884 @default.
- W2321793958 cites W2007700656 @default.
- W2321793958 cites W2011338213 @default.
- W2321793958 cites W2018815492 @default.
- W2321793958 cites W2030855575 @default.
- W2321793958 cites W2031765854 @default.
- W2321793958 cites W2034082915 @default.
- W2321793958 cites W2040653998 @default.
- W2321793958 cites W2044645765 @default.
- W2321793958 cites W2045892419 @default.
- W2321793958 cites W2053717384 @default.
- W2321793958 cites W2055094488 @default.
- W2321793958 cites W2057256337 @default.
- W2321793958 cites W2058324206 @default.
- W2321793958 cites W2060636173 @default.
- W2321793958 cites W2061987838 @default.
- W2321793958 cites W2070975187 @default.
- W2321793958 cites W2083256666 @default.
- W2321793958 cites W2085521487 @default.
- W2321793958 cites W2085752055 @default.
- W2321793958 cites W2086049041 @default.
- W2321793958 cites W2095253963 @default.
- W2321793958 cites W2101588077 @default.
- W2321793958 cites W2117736028 @default.
- W2321793958 cites W2120208739 @default.
- W2321793958 cites W2138986864 @default.
- W2321793958 cites W2139642025 @default.
- W2321793958 cites W2143737916 @default.
- W2321793958 cites W2144884256 @default.
- W2321793958 cites W2145643134 @default.
- W2321793958 cites W2146388575 @default.
- W2321793958 cites W2150804226 @default.
- W2321793958 cites W2151888549 @default.
- W2321793958 cites W2152456210 @default.
- W2321793958 cites W2157010562 @default.
- W2321793958 cites W2161914110 @default.
- W2321793958 cites W2162092658 @default.
- W2321793958 cites W2167938176 @default.
- W2321793958 cites W2171873266 @default.
- W2321793958 cites W4231313083 @default.
- W2321793958 cites W4237365916 @default.
- W2321793958 doi "https://doi.org/10.1097/mot.0b013e32835ef1eb" @default.
- W2321793958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23449345" @default.
- W2321793958 hasPublicationYear "2013" @default.
- W2321793958 type Work @default.
- W2321793958 sameAs 2321793958 @default.
- W2321793958 citedByCount "58" @default.
- W2321793958 countsByYear W23217939582013 @default.
- W2321793958 countsByYear W23217939582014 @default.
- W2321793958 countsByYear W23217939582015 @default.
- W2321793958 countsByYear W23217939582016 @default.
- W2321793958 countsByYear W23217939582017 @default.
- W2321793958 countsByYear W23217939582018 @default.
- W2321793958 countsByYear W23217939582019 @default.
- W2321793958 countsByYear W23217939582020 @default.
- W2321793958 countsByYear W23217939582021 @default.
- W2321793958 countsByYear W23217939582022 @default.
- W2321793958 countsByYear W23217939582023 @default.
- W2321793958 crossrefType "journal-article" @default.
- W2321793958 hasAuthorship W2321793958A5000883920 @default.
- W2321793958 hasAuthorship W2321793958A5019509998 @default.
- W2321793958 hasAuthorship W2321793958A5027604191 @default.
- W2321793958 hasAuthorship W2321793958A5041852736 @default.
- W2321793958 hasAuthorship W2321793958A5056788680 @default.
- W2321793958 hasAuthorship W2321793958A5071970006 @default.
- W2321793958 hasConcept C126322002 @default.
- W2321793958 hasConcept C136449434 @default.
- W2321793958 hasConcept C193419808 @default.
- W2321793958 hasConcept C203014093 @default.
- W2321793958 hasConcept C2780114680 @default.
- W2321793958 hasConcept C2911091166 @default.
- W2321793958 hasConcept C3019368612 @default.
- W2321793958 hasConcept C541997718 @default.
- W2321793958 hasConcept C71924100 @default.