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- W2321806281 abstract "The effects of prednisolone (PSL) on physiological factors, i. e. plasma lipids and blood proteins regulating cyclosporin A (CsA) blood distribution were evaluated in renal transplant patients. The clinical data of 46 blood samples from 10 outpatients with a stable renal function, who received CsA and low dose PSL (10 mg/day), were thus analyzed. The PSL concentration in plasma (CPSL) showed a significant positive correlation with hematocrit (HCT) and total cholesterol (CHO) but not with any other clinical laboratory tests related to either protein or lipid metabolism. In a multiple regression analysis the contribution that selected variables made to the CsA trough level was as follows: CHO > HCT >dose of CsA >CPSL. This finding suggests that the drug-interaction between PSL and CsA was much due more to either the changes in the physiological factors regulating the CsA blood distribution via protein anabolism or the unusual lipid metabolism of PSL than dut to the enzyme-inducing action of PSL for CsA. Taking the PSL concentration in plasma and the effects of PSL on protein or lipid metabolism into consideration, it is thus possible to optimize the effect of immunosuppressive therapy in renal transplant patients." @default.
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- W2321806281 date "1997-01-01" @default.
- W2321806281 modified "2023-10-04" @default.
- W2321806281 title "Effects of Prednisolone on the Physiological Factors Regulating Cyclosporin A Blood Distribution in Renal Transplant Patients." @default.
- W2321806281 doi "https://doi.org/10.5649/jjphcs1975.23.289" @default.
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