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- W2321808554 abstract ". CD24 v polymorphism associated with clinical progression of multiple sclerosis in a patient group Centro Medico Nacional 20 de Noviembre, ISSSTE ABSTRACT Introduction: Multiple sclerosis (MS) is the most frequent demyelinating disease of central nervous system, in which previous reports found an association between the polymorphisms of CD24 and the progression of the disease. Objectives: To identify the polymorphism of CD24 in MS patients and their controls; to get the allelic frequency of CD24 v polymorphism in patients with MS and controls; to associate the different CD24 v genotypes with the clinical evolution of patients with MS. Material and methods: Transversal, opened study, with 50 subjects and 50 controls between 18 and 65 years old. We use PCR and restriction fragment long polimorfism (RFLPs) techniques for CD24 v polymorphism determination. We compared the results using the Chi square test. Results: We found the CD24 v polymorphism in 4% of homocygotic alleles. We did not find any association between the presence of the polymorphism and the progression of MS. Conclusion: It is necessary a bigger sample of subjects with MS to confirm or not the presence of CD24 protein mutation in Mexican people with MS. Keys works: Multiple sclerosis, association, polymorphism, CD24 v ." @default.
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- W2321808554 date "2009-01-01" @default.
- W2321808554 modified "2023-09-24" @default.
- W2321808554 title "Análisis del polimorfismo CD24v asociado a la progresión clínica de la esclerosis múltiple en un grupo de pacientes del Centro Médico Nacional 20 de Noviembre del ISSSTE" @default.
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