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- W2321810786 abstract "Opioid-based narcotics are a major component of pain management, but are problematic due to negative side effects mediated by the central nervous system. Pain management can be optimized through discovery of potent non-opioid therapeutics, as well as targeting the peripheral nervous system to avoid side effects. A subpopulation of sensory neurons expresses the transient receptor potential V1 ion channel (TRPV1), gated by capsaicin and noxious heat. TRPV1 activation induces release of proinflammatory peptides, including calcitonin gene-related peptide (CGRP), contributing to peripheral sensitization and leading to hyperalgesia. Potent agonists targeting TRPV1, such as capsaicin and resiniferatoxin, produce peripheral analgesia via TRPV1 desensitization and ablation of TRPV1-expressing nociceptors. Resiniferatoxin is extracted from the latex of Euphorbia resinifera. In the same family, Euphorbia bicolor (Euphorbiaceae), native to the Southern United States, displays antioxidant and antiestrogenic properties. E. bicolor latex shares similar phytochemicals, including the irritant Euphorbium, thus may share analgesic properties. We hypothesized that, if the latex of E. bicolor and E. resinifera are similar, then the extract of E. bicolor would initially increase CGRP release from sensory neurons followed by a decrease in capsaicin-evoked CGRP release. Rats were decapitated and trigeminal ganglia removed, dissociated, and cultured for 5 days. Cells were then washed and treated with buffer for 15 minutes. Fractions were collected and cells were treated with either vehicle or E. bicolor latex (0, 25, 50, 100, 300 μg/mL) for 15 minutes followed by treatment with vehicle or E. bicolor latex co-treated with capsaicin (50 nM). CGRP was quantified by ELISA. E. bicolor latex treatment induced a twofold increase in CGRP release from trigeminal sensory neurons, similar to the amount of CGRP release stimulated by capsaicin. Capsaicin-stimulated release was reduced following latex treatment compared to vehicle. These data indicate that E. bicolor latex may display similar analgesic properties to TRPV1 agonists." @default.
- W2321810786 created "2016-06-24" @default.
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- W2321810786 date "2016-04-01" @default.
- W2321810786 modified "2023-09-27" @default.
- W2321810786 title "(427) Novel effects of Euphorbia bicolor (Euphorbiaceae) latex extract on nociceptors" @default.
- W2321810786 doi "https://doi.org/10.1016/j.jpain.2016.01.404" @default.
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