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- W2321813449 abstract "In the previous papers we reported that the antibiotic Polyoxin D induced the characteristic swelling of the mycelia of fungi, 1, 2) and strongly inhibited the incorporation of 14C-glucosamine into the fungal cell wall chitin.3) The present work has been conducted to further investigate the influence of this antibiotic on the fungal cell wall biosynthesis. Polyoxin D did not inhibit the incorporation of 14C-glucose, 14C-amino acids and 14C-sodium acetate into the cell wall. In addition, UDP-N-acetylglucosamine, a precurcor of chitin biosynthesis of cell wall, was accumulated in the Polyoxin D-treated mycelia of Cochliobolus miyabeanus more than 150 to 160% of that accumulated in the untreated one. Chitin synthetase prepared from Piricularia oryzae which is not treated with Polyoxin D was completely inhibited by the addition of 0.1ppm of Polyoxin D. The fungitoxicity of Polyoxins A to G was positively related to their inhibition of 14C-glucosamine incorporation into the cell wall chitin of C. miyabeanus. From above results, it became evident that the antibiotic Polyoxin complex inhibited the biosynthesis of fungal cell wall chitin." @default.
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- W2321813449 date "1970-01-01" @default.
- W2321813449 modified "2023-09-26" @default.
- W2321813449 title "Studies on the Mode of Action of Polyoxin D" @default.
- W2321813449 doi "https://doi.org/10.1271/bbb1961.34.1224" @default.
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