Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321813770> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2321813770 endingPage "178" @default.
- W2321813770 startingPage "168" @default.
- W2321813770 abstract "Despite potential adverse effects, clinical use of amiodarone is increasing because of its efficacy in treating arrhythmias. Thus there is a continued need for a rapid, practical amiodarone assay to better study the relationship between serum concentrations and clinical effects and to guide safer dosing. Because the most widely used internal standard, L8040, is no longer available, a systematic comparison of potential alternatives was undertaken based on physicochemical and chromatographic characteristics. All amiodarone assays indexed on Medline were reviewed to produce a list of alternatives and five other potential substances considered based on previous experiences. An isocratic high-performance liquid chromatographic method was modified to allow simultaneous resolution of multiple compounds. The internal standard was expected to perform well in the solid-phase extraction of small sample volumes. No commercially available substances were able to duplicate all the advantages of L8040. Tamoxifen, the most acceptable alternative, was used to develop an assay to measure amiodarone and desethylamiodarone at concentrations as low as 0.25 mg/L in 100 microliters of serum (5 ng detected in a 20 microliters injection). Standard curves were linear over the range of concentrations found in our patients (0.25 to 8 mg/L), within-run coefficients of variation (CVs) averaged 5.3% for amiodarone and 2.9% for desethylamiodarone, and between-run CVs were 4.5% for amiodarone and 1.6% for desethylamiodarone." @default.
- W2321813770 created "2016-06-24" @default.
- W2321813770 creator A5055834410 @default.
- W2321813770 date "1996-04-01" @default.
- W2321813770 modified "2023-09-27" @default.
- W2321813770 title "A Systematic Review and Critical Comparison of Internal Standards for the Routine Liquid Chromatographic Assay of Amiodarone and Desethylamiodarone" @default.
- W2321813770 cites W1841210729 @default.
- W2321813770 cites W1894243326 @default.
- W2321813770 cites W1965693851 @default.
- W2321813770 cites W1969763942 @default.
- W2321813770 cites W1971354741 @default.
- W2321813770 cites W1982973712 @default.
- W2321813770 cites W1988057529 @default.
- W2321813770 cites W1990076321 @default.
- W2321813770 cites W2001573410 @default.
- W2321813770 cites W2002374666 @default.
- W2321813770 cites W2007042357 @default.
- W2321813770 cites W2013128456 @default.
- W2321813770 cites W2014543829 @default.
- W2321813770 cites W2027100423 @default.
- W2321813770 cites W2030698332 @default.
- W2321813770 cites W2039028691 @default.
- W2321813770 cites W2049483999 @default.
- W2321813770 cites W2051395084 @default.
- W2321813770 cites W2052157878 @default.
- W2321813770 cites W2055306536 @default.
- W2321813770 cites W2056448400 @default.
- W2321813770 cites W2057181135 @default.
- W2321813770 cites W2058640270 @default.
- W2321813770 cites W2066789391 @default.
- W2321813770 cites W2068459390 @default.
- W2321813770 cites W2075611809 @default.
- W2321813770 cites W2076130054 @default.
- W2321813770 cites W2077865259 @default.
- W2321813770 cites W2079017227 @default.
- W2321813770 cites W2079152508 @default.
- W2321813770 cites W2086952317 @default.
- W2321813770 cites W2086997784 @default.
- W2321813770 cites W2089577814 @default.
- W2321813770 cites W2095543086 @default.
- W2321813770 cites W2112829244 @default.
- W2321813770 cites W2129971599 @default.
- W2321813770 cites W2141513083 @default.
- W2321813770 cites W2155171410 @default.
- W2321813770 cites W2246127389 @default.
- W2321813770 cites W288259550 @default.
- W2321813770 cites W4299332001 @default.
- W2321813770 cites W4300907785 @default.
- W2321813770 cites W4302555875 @default.
- W2321813770 doi "https://doi.org/10.1097/00007691-199604000-00011" @default.
- W2321813770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8721281" @default.
- W2321813770 hasPublicationYear "1996" @default.
- W2321813770 type Work @default.
- W2321813770 sameAs 2321813770 @default.
- W2321813770 citedByCount "19" @default.
- W2321813770 countsByYear W23218137702012 @default.
- W2321813770 crossrefType "journal-article" @default.
- W2321813770 hasAuthorship W2321813770A5055834410 @default.
- W2321813770 hasConcept C126322002 @default.
- W2321813770 hasConcept C185592680 @default.
- W2321813770 hasConcept C2777288759 @default.
- W2321813770 hasConcept C2778094803 @default.
- W2321813770 hasConcept C2779161974 @default.
- W2321813770 hasConcept C43617362 @default.
- W2321813770 hasConcept C71924100 @default.
- W2321813770 hasConcept C98274493 @default.
- W2321813770 hasConceptScore W2321813770C126322002 @default.
- W2321813770 hasConceptScore W2321813770C185592680 @default.
- W2321813770 hasConceptScore W2321813770C2777288759 @default.
- W2321813770 hasConceptScore W2321813770C2778094803 @default.
- W2321813770 hasConceptScore W2321813770C2779161974 @default.
- W2321813770 hasConceptScore W2321813770C43617362 @default.
- W2321813770 hasConceptScore W2321813770C71924100 @default.
- W2321813770 hasConceptScore W2321813770C98274493 @default.
- W2321813770 hasIssue "2" @default.
- W2321813770 hasLocation W23218137701 @default.
- W2321813770 hasLocation W23218137702 @default.
- W2321813770 hasOpenAccess W2321813770 @default.
- W2321813770 hasPrimaryLocation W23218137701 @default.
- W2321813770 hasRelatedWork W2014195660 @default.
- W2321813770 hasRelatedWork W2031025443 @default.
- W2321813770 hasRelatedWork W2091940969 @default.
- W2321813770 hasRelatedWork W2151610778 @default.
- W2321813770 hasRelatedWork W2416180887 @default.
- W2321813770 hasRelatedWork W2748952813 @default.
- W2321813770 hasRelatedWork W2899084033 @default.
- W2321813770 hasRelatedWork W3012508844 @default.
- W2321813770 hasRelatedWork W4285112429 @default.
- W2321813770 hasRelatedWork W4322724425 @default.
- W2321813770 hasVolume "18" @default.
- W2321813770 isParatext "false" @default.
- W2321813770 isRetracted "false" @default.
- W2321813770 magId "2321813770" @default.
- W2321813770 workType "article" @default.