FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321814733> ?p ?o ?g. }

• W2321814733 endingPage "1191" @default.
• W2321814733 startingPage "1185" @default.
• W2321814733 abstract "Cytotoxicity of 6-HO-BDE-47 and its two analogues, BDE-47 and 6-MeO-BDE-47, and the associated molecular mechanisms were assessed by use of a live cell reporter assay system which contains a library of 1820 modified green fluorescent protein (GFP) expressing promoter reporter vectors constructed from E. coli K12 strains. 6-HO-BDE-47 inhibited growth of E. coli with a 4 h median effect concentration (EC50) of 22.52 ± 2.20 mg/L, but neither BDE-47 nor 6-MeO-BDE-47 were cytotoxic. Thus, 6-HO-BDE-47 might serve as an antibiotic in some living organisms. Exposure to 6-HO-BDE-47 resulted in 65 (fold change >2) or 129 (fold change >1.5) genes being differentially expressed. The no observed transcriptional effect concentration (NOTEC) and median transcriptional effect concentration (TEC50) based on transcriptional end points, of 6-HO-BDE-47 were 0.0438 and 0.580 mg/L, respectively. The transcriptional responses were 514- and 39-fold more sensitive than the acute EC50 to inhibit cell growth. Most of the genes that were differentially expressed in response to 6-HO-BDE-47 were not modulated by BDE-47 or 6-MeO-BDE-47. These results suggest that cytotoxicity of 6-HO-BDE-47 to E. coli was via a mechanism that was different from that of either BDE-47 or 6-MeO-BDE-47. Gene expression associated with metabolic pathways was more responsive to 6-HO-BDE-47, which suggests that this pathway might be the primary target of this compound." @default.
• W2321814733 created "2016-06-24" @default.
• W2321814733 creator A5000852341 @default.
• W2321814733 creator A5009044499 @default.
• W2321814733 creator A5017756377 @default.
• W2321814733 creator A5021866182 @default.
• W2321814733 creator A5033111260 @default.
• W2321814733 creator A5039895229 @default.
• W2321814733 creator A5042994188 @default.
• W2321814733 creator A5046284615 @default.
• W2321814733 creator A5066881109 @default.
• W2321814733 creator A5072896488 @default.
• W2321814733 date "2011-12-19" @default.
• W2321814733 modified "2023-09-26" @default.
• W2321814733 title "Toxicogenomic Mechanisms of 6-HO-BDE-47, 6-MeO-BDE-47, and BDE-47 in <i>E. coli</i>" @default.
• W2321814733 cites W1965507459 @default.
• W2321814733 cites W1968234458 @default.
• W2321814733 cites W1970006572 @default.
• W2321814733 cites W1972087323 @default.
• W2321814733 cites W1973412840 @default.
• W2321814733 cites W1999673948 @default.
• W2321814733 cites W2007476051 @default.
• W2321814733 cites W2017432477 @default.
• W2321814733 cites W2020325329 @default.
• W2321814733 cites W2024515734 @default.
• W2321814733 cites W2024771105 @default.
• W2321814733 cites W2030955215 @default.
• W2321814733 cites W2038186289 @default.
• W2321814733 cites W2040874069 @default.
• W2321814733 cites W2043075433 @default.
• W2321814733 cites W2046182000 @default.
• W2321814733 cites W2046323514 @default.
• W2321814733 cites W2059153557 @default.
• W2321814733 cites W2064544131 @default.
• W2321814733 cites W2068768382 @default.
• W2321814733 cites W2080688660 @default.
• W2321814733 cites W2095567595 @default.
• W2321814733 cites W2100492886 @default.
• W2321814733 cites W2109561093 @default.
• W2321814733 cites W2116207162 @default.
• W2321814733 cites W2140545824 @default.
• W2321814733 cites W2143741133 @default.
• W2321814733 cites W2145671732 @default.
• W2321814733 cites W2155142785 @default.
• W2321814733 cites W2159675211 @default.
• W2321814733 cites W2312195075 @default.
• W2321814733 cites W2332474866 @default.
• W2321814733 doi "https://doi.org/10.1021/es203212w" @default.
• W2321814733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22111525" @default.
• W2321814733 hasPublicationYear "2011" @default.
• W2321814733 type Work @default.
• W2321814733 sameAs 2321814733 @default.
• W2321814733 citedByCount "38" @default.
• W2321814733 countsByYear W23218147332012 @default.
• W2321814733 countsByYear W23218147332013 @default.
• W2321814733 countsByYear W23218147332014 @default.
• W2321814733 countsByYear W23218147332015 @default.
• W2321814733 countsByYear W23218147332016 @default.
• W2321814733 countsByYear W23218147332017 @default.
• W2321814733 countsByYear W23218147332018 @default.
• W2321814733 countsByYear W23218147332019 @default.
• W2321814733 countsByYear W23218147332020 @default.
• W2321814733 countsByYear W23218147332021 @default.
• W2321814733 countsByYear W23218147332022 @default.
• W2321814733 crossrefType "journal-article" @default.
• W2321814733 hasAuthorship W2321814733A5000852341 @default.
• W2321814733 hasAuthorship W2321814733A5009044499 @default.
• W2321814733 hasAuthorship W2321814733A5017756377 @default.
• W2321814733 hasAuthorship W2321814733A5021866182 @default.
• W2321814733 hasAuthorship W2321814733A5033111260 @default.
• W2321814733 hasAuthorship W2321814733A5039895229 @default.
• W2321814733 hasAuthorship W2321814733A5042994188 @default.
• W2321814733 hasAuthorship W2321814733A5046284615 @default.
• W2321814733 hasAuthorship W2321814733A5066881109 @default.
• W2321814733 hasAuthorship W2321814733A5072896488 @default.
• W2321814733 hasConcept C104317684 @default.
• W2321814733 hasConcept C109316439 @default.
• W2321814733 hasConcept C150194340 @default.
• W2321814733 hasConcept C153911025 @default.
• W2321814733 hasConcept C161733203 @default.
• W2321814733 hasConcept C185592680 @default.
• W2321814733 hasConcept C202751555 @default.
• W2321814733 hasConcept C547475151 @default.
• W2321814733 hasConcept C55493867 @default.
• W2321814733 hasConcept C86803240 @default.
• W2321814733 hasConcept C96529984 @default.
• W2321814733 hasConceptScore W2321814733C104317684 @default.
• W2321814733 hasConceptScore W2321814733C109316439 @default.
• W2321814733 hasConceptScore W2321814733C150194340 @default.
• W2321814733 hasConceptScore W2321814733C153911025 @default.
• W2321814733 hasConceptScore W2321814733C161733203 @default.
• W2321814733 hasConceptScore W2321814733C185592680 @default.
• W2321814733 hasConceptScore W2321814733C202751555 @default.
• W2321814733 hasConceptScore W2321814733C547475151 @default.
• W2321814733 hasConceptScore W2321814733C55493867 @default.
• W2321814733 hasConceptScore W2321814733C86803240 @default.
• W2321814733 hasConceptScore W2321814733C96529984 @default.
• W2321814733 hasIssue "2" @default.

• next