FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321818004> ?p ?o ?g. }

• W2321818004 endingPage "2508" @default.
• W2321818004 startingPage "2502" @default.
• W2321818004 abstract "These studies explore the relationship between the inhibitory actions of low generation dendrimers in stimulated microglia and dendrimer-enzyme interactions using in silico molecular modeling. Low generation (DG0 and DG1) dendrimers with acetylene and hydroxyl terminal groups were tested for their anti-inflammatory activity in microglia stimulated by lipopolysaccharides (LPS), and the results were compared with those from the established anti-inflammatory agents, ibuprofen and celecoxib. We hypothesized that hydroxyl terminal groups of DG0 and DG1 dendrimers could interact with the active sites of the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) enzymes due to their small size and favorable electrochemical properties. The enzymatic activity of iNOS and COX-2 was determined in the presence of low generation dendrimers using biochemical assays and their values related to dendrimer docking confirmations from in silico molecular modeling. We found that results from the molecular modeling studies correlated well with the in vitro biological data, suggesting that, indeed, hydroxyl terminal groups of low generation dendrimers enable multivalent macromolecular interactions, resulting in the inhibition of both iNOS and COX-2 enzymes." @default.
• W2321818004 created "2016-06-24" @default.
• W2321818004 creator A5012673291 @default.
• W2321818004 creator A5017648912 @default.
• W2321818004 creator A5020782570 @default.
• W2321818004 creator A5025211379 @default.
• W2321818004 creator A5052306927 @default.
• W2321818004 creator A5056385313 @default.
• W2321818004 creator A5085289929 @default.
• W2321818004 date "2013-05-02" @default.
• W2321818004 modified "2023-09-23" @default.
• W2321818004 title "“Click” Dendrimers as Anti-inflammatory Agents: With Insights into Their Binding from Molecular Modeling Studies" @default.
• W2321818004 cites W1975081245 @default.
• W2321818004 cites W1984463125 @default.
• W2321818004 cites W1995193883 @default.
• W2321818004 cites W2006454411 @default.
• W2321818004 cites W2012992792 @default.
• W2321818004 cites W2013875806 @default.
• W2321818004 cites W2020381186 @default.
• W2321818004 cites W2023553716 @default.
• W2321818004 cites W2032840656 @default.
• W2321818004 cites W2063741056 @default.
• W2321818004 cites W2067643341 @default.
• W2321818004 cites W2072952339 @default.
• W2321818004 cites W2075281009 @default.
• W2321818004 cites W2078475087 @default.
• W2321818004 cites W2090509304 @default.
• W2321818004 cites W2090983971 @default.
• W2321818004 cites W2094761607 @default.
• W2321818004 cites W2141730948 @default.
• W2321818004 cites W2161013573 @default.
• W2321818004 cites W2163987144 @default.
• W2321818004 cites W2164594351 @default.
• W2321818004 cites W2500266776 @default.
• W2321818004 doi "https://doi.org/10.1021/mp4000508" @default.
• W2321818004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23590185" @default.
• W2321818004 hasPublicationYear "2013" @default.
• W2321818004 type Work @default.
• W2321818004 sameAs 2321818004 @default.
• W2321818004 citedByCount "33" @default.
• W2321818004 countsByYear W23218180042013 @default.
• W2321818004 countsByYear W23218180042014 @default.
• W2321818004 countsByYear W23218180042015 @default.
• W2321818004 countsByYear W23218180042016 @default.
• W2321818004 countsByYear W23218180042017 @default.
• W2321818004 countsByYear W23218180042018 @default.
• W2321818004 countsByYear W23218180042019 @default.
• W2321818004 countsByYear W23218180042020 @default.
• W2321818004 countsByYear W23218180042021 @default.
• W2321818004 countsByYear W23218180042022 @default.
• W2321818004 countsByYear W23218180042023 @default.
• W2321818004 crossrefType "journal-article" @default.
• W2321818004 hasAuthorship W2321818004A5012673291 @default.
• W2321818004 hasAuthorship W2321818004A5017648912 @default.
• W2321818004 hasAuthorship W2321818004A5020782570 @default.
• W2321818004 hasAuthorship W2321818004A5025211379 @default.
• W2321818004 hasAuthorship W2321818004A5052306927 @default.
• W2321818004 hasAuthorship W2321818004A5056385313 @default.
• W2321818004 hasAuthorship W2321818004A5085289929 @default.
• W2321818004 hasBestOaLocation W23218180042 @default.
• W2321818004 hasConcept C104317684 @default.
• W2321818004 hasConcept C12554922 @default.
• W2321818004 hasConcept C159110408 @default.
• W2321818004 hasConcept C178790620 @default.
• W2321818004 hasConcept C178910836 @default.
• W2321818004 hasConcept C181199279 @default.
• W2321818004 hasConcept C185592680 @default.
• W2321818004 hasConcept C202751555 @default.
• W2321818004 hasConcept C2775905019 @default.
• W2321818004 hasConcept C2777622882 @default.
• W2321818004 hasConcept C2779689624 @default.
• W2321818004 hasConcept C41685203 @default.
• W2321818004 hasConcept C519581460 @default.
• W2321818004 hasConcept C55493867 @default.
• W2321818004 hasConcept C55637122 @default.
• W2321818004 hasConcept C71924100 @default.
• W2321818004 hasConcept C86803240 @default.
• W2321818004 hasConceptScore W2321818004C104317684 @default.
• W2321818004 hasConceptScore W2321818004C12554922 @default.
• W2321818004 hasConceptScore W2321818004C159110408 @default.
• W2321818004 hasConceptScore W2321818004C178790620 @default.
• W2321818004 hasConceptScore W2321818004C178910836 @default.
• W2321818004 hasConceptScore W2321818004C181199279 @default.
• W2321818004 hasConceptScore W2321818004C185592680 @default.
• W2321818004 hasConceptScore W2321818004C202751555 @default.
• W2321818004 hasConceptScore W2321818004C2775905019 @default.
• W2321818004 hasConceptScore W2321818004C2777622882 @default.
• W2321818004 hasConceptScore W2321818004C2779689624 @default.
• W2321818004 hasConceptScore W2321818004C41685203 @default.
• W2321818004 hasConceptScore W2321818004C519581460 @default.
• W2321818004 hasConceptScore W2321818004C55493867 @default.
• W2321818004 hasConceptScore W2321818004C55637122 @default.
• W2321818004 hasConceptScore W2321818004C71924100 @default.
• W2321818004 hasConceptScore W2321818004C86803240 @default.
• W2321818004 hasIssue "6" @default.
• W2321818004 hasLocation W23218180041 @default.
• W2321818004 hasLocation W23218180042 @default.
• W2321818004 hasLocation W23218180043 @default.

• next