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- W2321820015 abstract "Introduction: Hepatoportal sclerosis (HPS), first report by Mikkelsen et al in 1965, is a clinic pathologic condition that causes no cirrhotic portal hypertension. In HPS; the primary hepatic lesion is found in the portal vein branches. In general, hepatic synthetic function is preserved. Rarely patients with HPS need liver transplantation. The Aim of this study is to present the clinical and pathologic features of six HPS cases that underwent liver transplantation (LT) Methods/Results: From 1999 to 2008, 6 LT patients were diagnosed with HPS. Three patients with bleeding varices and four had concomitant ascites. Child-Pugh evaluation was B in four patients and C in two cases. MELD score was 18 in two cases, 20 in three patients and 22 in one patients. Cirrhosis resulting from alcohol (1), autoimmune (2), cryptogenic cirrhosis (3) was the presumed diagnosis pre LT. On histological examination, there was marked phlebo-sclerosis in all cases, non occlusive portal vein thrombosis in 3 cases, intense portal fibrosis in one case, moderate portal fibrosis in 5 cases, moderate sinusoidal dilatation in all cases, none mega sinusoid formation, ductal biliar proliferation and ductal biliar fibrosis was observed in all cases, colestasis was found in one case, incomplete septal cirrhosis was observed in 4 cases. None showed histological features of the presumed underlying liver disease. The overall survival of this group was no different to that seen in other LT patients underwent for other causes. Conclusion: HPS can cause hepatic failure and may require liver transplantation. Significant portal fibrosis and phlebo-sclerosis may contribute to hepatic parenchyma loss and posterior synthetic loss." @default.
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- W2321820015 date "2012-11-01" @default.
- W2321820015 modified "2023-10-14" @default.
- W2321820015 title "Liver Failure and the Need for Transplantation in Six Patients with Hepatoportal Sclerosis" @default.
- W2321820015 doi "https://doi.org/10.1097/00007890-201211271-01306" @default.
- W2321820015 hasPublicationYear "2012" @default.
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