FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321822450> ?p ?o ?g. }

• W2321822450 endingPage "885" @default.
• W2321822450 startingPage "874" @default.
• W2321822450 abstract "The stereoselective pharmacokinetics of the four stereoisomers [FK176 (2R, 4R- and 2S, 4S-isomer) and FK177 (2R, 4S- and 2S, 4R-isomer)] of 4-(dimethylamino)-2-phenyl-2-(2-pyridyl)pentanamide were studied in rats. 1. When racemic FK176 (vamicamide) was orally administered to rats at 10 mg/kg, there were no stereoselective differences in the pharmacokinetics of 2R, 4R and 2S, 4S-enantiomer. 2. When racemic FK177 was orally administered to rats at 10 mg/kg, the mean Cmax and AUC values for the 2R, 4S-enantiomer were 2.0 and 3.0 times greater, respectively, than those for the 2S, 4R-enantiomer. 3. Serum protein binding of four stereoisomers were very low and there was no appreciable difference. 4. Rat hepatic microsomes metabolized 2S, 4R-isomer faster than 2R, 4R-, 2S, 4S and 2R, 4S-isomer. 2S, 4R-isomer was mainly metabolized to aryl hydroxylated metabolite. 5. Eight metabolites, M-I to M-V and M-B to M-D, were isolated from bile samples collected from rats after oral administration of FK176 or 2S, 4R-isomer. The structures of these metabolites were characterized by mass spectrometry and were comfirmed by comparison with reference compounds. 6. Finally, we concluded that the stereoselective differences in serum levels of 2S, 4R isomer were caused by stereoselective hepatic metabolism." @default.
• W2321822450 created "2016-06-24" @default.
• W2321822450 creator A5008919882 @default.
• W2321822450 creator A5017776579 @default.
• W2321822450 creator A5018665174 @default.
• W2321822450 creator A5030338860 @default.
• W2321822450 creator A5035391932 @default.
• W2321822450 creator A5043240967 @default.
• W2321822450 date "1994-01-01" @default.
• W2321822450 modified "2023-10-12" @default.
• W2321822450 title "Stereoselective Pharmacokinetics of the Four Stereoisomers of 4-(Dimethylamino)-2-phenyl-2-(2-pyridyl)pentanamide in Rats." @default.
• W2321822450 cites W1980873148 @default.
• W2321822450 cites W1991539614 @default.
• W2321822450 cites W2032998126 @default.
• W2321822450 cites W2036570914 @default.
• W2321822450 cites W2064127809 @default.
• W2321822450 cites W2413662072 @default.
• W2321822450 doi "https://doi.org/10.2133/dmpk.9.874" @default.
• W2321822450 hasPublicationYear "1994" @default.
• W2321822450 type Work @default.
• W2321822450 sameAs 2321822450 @default.
• W2321822450 citedByCount "1" @default.
• W2321822450 countsByYear W23218224502020 @default.
• W2321822450 crossrefType "journal-article" @default.
• W2321822450 hasAuthorship W2321822450A5008919882 @default.
• W2321822450 hasAuthorship W2321822450A5017776579 @default.
• W2321822450 hasAuthorship W2321822450A5018665174 @default.
• W2321822450 hasAuthorship W2321822450A5030338860 @default.
• W2321822450 hasAuthorship W2321822450A5035391932 @default.
• W2321822450 hasAuthorship W2321822450A5043240967 @default.
• W2321822450 hasBestOaLocation W23218224501 @default.
• W2321822450 hasConcept C112705442 @default.
• W2321822450 hasConcept C129694887 @default.
• W2321822450 hasConcept C161790260 @default.
• W2321822450 hasConcept C178790620 @default.
• W2321822450 hasConcept C181199279 @default.
• W2321822450 hasConcept C181647583 @default.
• W2321822450 hasConcept C185592680 @default.
• W2321822450 hasConcept C22979827 @default.
• W2321822450 hasConcept C2777056448 @default.
• W2321822450 hasConcept C2777477808 @default.
• W2321822450 hasConcept C2780263894 @default.
• W2321822450 hasConcept C2781076698 @default.
• W2321822450 hasConcept C32909587 @default.
• W2321822450 hasConcept C486523 @default.
• W2321822450 hasConcept C55493867 @default.
• W2321822450 hasConcept C62231903 @default.
• W2321822450 hasConcept C71240020 @default.
• W2321822450 hasConcept C86803240 @default.
• W2321822450 hasConcept C87644729 @default.
• W2321822450 hasConcept C98274493 @default.
• W2321822450 hasConceptScore W2321822450C112705442 @default.
• W2321822450 hasConceptScore W2321822450C129694887 @default.
• W2321822450 hasConceptScore W2321822450C161790260 @default.
• W2321822450 hasConceptScore W2321822450C178790620 @default.
• W2321822450 hasConceptScore W2321822450C181199279 @default.
• W2321822450 hasConceptScore W2321822450C181647583 @default.
• W2321822450 hasConceptScore W2321822450C185592680 @default.
• W2321822450 hasConceptScore W2321822450C22979827 @default.
• W2321822450 hasConceptScore W2321822450C2777056448 @default.
• W2321822450 hasConceptScore W2321822450C2777477808 @default.
• W2321822450 hasConceptScore W2321822450C2780263894 @default.
• W2321822450 hasConceptScore W2321822450C2781076698 @default.
• W2321822450 hasConceptScore W2321822450C32909587 @default.
• W2321822450 hasConceptScore W2321822450C486523 @default.
• W2321822450 hasConceptScore W2321822450C55493867 @default.
• W2321822450 hasConceptScore W2321822450C62231903 @default.
• W2321822450 hasConceptScore W2321822450C71240020 @default.
• W2321822450 hasConceptScore W2321822450C86803240 @default.
• W2321822450 hasConceptScore W2321822450C87644729 @default.
• W2321822450 hasConceptScore W2321822450C98274493 @default.
• W2321822450 hasIssue "6" @default.
• W2321822450 hasLocation W23218224501 @default.
• W2321822450 hasOpenAccess W2321822450 @default.
• W2321822450 hasPrimaryLocation W23218224501 @default.
• W2321822450 hasRelatedWork W1517289359 @default.
• W2321822450 hasRelatedWork W1561149179 @default.
• W2321822450 hasRelatedWork W1596035812 @default.
• W2321822450 hasRelatedWork W1799172199 @default.
• W2321822450 hasRelatedWork W1817629323 @default.
• W2321822450 hasRelatedWork W1981132132 @default.
• W2321822450 hasRelatedWork W2004633456 @default.
• W2321822450 hasRelatedWork W2019851071 @default.
• W2321822450 hasRelatedWork W2094245303 @default.
• W2321822450 hasRelatedWork W2096854626 @default.
• W2321822450 hasRelatedWork W2097200204 @default.
• W2321822450 hasRelatedWork W2137901238 @default.
• W2321822450 hasRelatedWork W2157544 @default.
• W2321822450 hasRelatedWork W2159481015 @default.
• W2321822450 hasRelatedWork W2164139563 @default.
• W2321822450 hasRelatedWork W2295583135 @default.
• W2321822450 hasRelatedWork W2316779293 @default.
• W2321822450 hasRelatedWork W2411223914 @default.
• W2321822450 hasRelatedWork W2017025489 @default.
• W2321822450 hasRelatedWork W21435082 @default.
• W2321822450 hasVolume "9" @default.
• W2321822450 isParatext "false" @default.
• W2321822450 isRetracted "false" @default.

• next