FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321822925> ?p ?o ?g. }

• W2321822925 endingPage "F852" @default.
• W2321822925 startingPage "F844" @default.
• W2321822925 abstract "We have recently demonstrated protection against renal ischemic-reperfusion injury in vivo by A(1)- and A(2a)-adenosine receptor (AR) modulations. To further elucidate the signaling cascades of AR-induced cytoprotection against reperfusion/oxidant-mediated injury, immortalized human proximal tubule (HK-2) cells were treated with H(2)O(2). H(2)O(2) caused dose- and time-dependent HK-2 cell death that was measured by lactate dehydrogenase release and trypan blue dye uptake. Adenosine protected against H(2)O(2)-induced HK-2 cell death by means of A(1)- and A(2a)-AR activation. A(1)-AR-mediated protection involves pertussis toxin-sensitive G proteins and protein kinase C, whereas A(2a)-AR-mediated protection involves protein kinase A activation by means of cAMP and activation of the cAMP response element binding protein. Moreover, protein kinase A activators (forskolin and Sp-isomer cAMP) also protected HK-2 cells against H(2)O(2) injury. De novo gene transcription and protein synthesis are required for both A(1)- and A(2a)-AR-mediated cytoprotection as actinomycin D and cycloheximide, respectively, blocked cytoprotection. Chronic treatments with a nonselective AR agonist abolished the protection by adenosine. Moreover, chronic treatments with a nonselective AR antagonist increased the endogenous tolerance of HK-2 cells against H(2)O(2). We concluded that A(1)- and A(2a)-AR activation protects HK-2 cells against H(2)O(2)-induced injury by means of distinct signaling pathways that require new gene transcription and new protein synthesis." @default.
• W2321822925 created "2016-06-24" @default.
• W2321822925 creator A5007570280 @default.
• W2321822925 creator A5012873342 @default.
• W2321822925 date "2002-05-01" @default.
• W2321822925 modified "2023-09-27" @default.
• W2321822925 title "Adenosine attenuates oxidant injury in human proximal tubular cells via A₁and A_2aadenosine receptors" @default.
• W2321822925 cites W1850950958 @default.
• W2321822925 cites W1965480868 @default.
• W2321822925 cites W1972061450 @default.
• W2321822925 cites W1979517515 @default.
• W2321822925 cites W1986169724 @default.
• W2321822925 cites W1986347387 @default.
• W2321822925 cites W1988428277 @default.
• W2321822925 cites W1988838635 @default.
• W2321822925 cites W1989335212 @default.
• W2321822925 cites W1989720567 @default.
• W2321822925 cites W1993034847 @default.
• W2321822925 cites W1997299202 @default.
• W2321822925 cites W2003671607 @default.
• W2321822925 cites W2004050326 @default.
• W2321822925 cites W2007376496 @default.
• W2321822925 cites W2011502131 @default.
• W2321822925 cites W2013372830 @default.
• W2321822925 cites W2015490429 @default.
• W2321822925 cites W2027071069 @default.
• W2321822925 cites W2031714315 @default.
• W2321822925 cites W2041117043 @default.
• W2321822925 cites W2042969011 @default.
• W2321822925 cites W2044074327 @default.
• W2321822925 cites W2047477057 @default.
• W2321822925 cites W2061266627 @default.
• W2321822925 cites W2067729477 @default.
• W2321822925 cites W2068187607 @default.
• W2321822925 cites W2092288827 @default.
• W2321822925 cites W2092451878 @default.
• W2321822925 cites W2092856484 @default.
• W2321822925 cites W2096035742 @default.
• W2321822925 cites W2117398210 @default.
• W2321822925 cites W2125716406 @default.
• W2321822925 cites W2129667982 @default.
• W2321822925 cites W2133203059 @default.
• W2321822925 cites W2234476533 @default.
• W2321822925 cites W2255226908 @default.
• W2321822925 cites W2261071161 @default.
• W2321822925 cites W2280388337 @default.
• W2321822925 cites W2303384780 @default.
• W2321822925 cites W2333153638 @default.
• W2321822925 cites W2338461762 @default.
• W2321822925 cites W2398159785 @default.
• W2321822925 cites W2406094731 @default.
• W2321822925 cites W2417611445 @default.
• W2321822925 doi "https://doi.org/10.1152/ajprenal.00195.2001" @default.
• W2321822925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11934694" @default.
• W2321822925 hasPublicationYear "2002" @default.
• W2321822925 type Work @default.
• W2321822925 sameAs 2321822925 @default.
• W2321822925 citedByCount "76" @default.
• W2321822925 countsByYear W23218229252012 @default.
• W2321822925 countsByYear W23218229252013 @default.
• W2321822925 countsByYear W23218229252014 @default.
• W2321822925 countsByYear W23218229252015 @default.
• W2321822925 countsByYear W23218229252016 @default.
• W2321822925 countsByYear W23218229252017 @default.
• W2321822925 countsByYear W23218229252018 @default.
• W2321822925 countsByYear W23218229252019 @default.
• W2321822925 countsByYear W23218229252020 @default.
• W2321822925 countsByYear W23218229252023 @default.
• W2321822925 crossrefType "journal-article" @default.
• W2321822925 hasAuthorship W2321822925A5007570280 @default.
• W2321822925 hasAuthorship W2321822925A5012873342 @default.
• W2321822925 hasConcept C153911025 @default.
• W2321822925 hasConcept C16587737 @default.
• W2321822925 hasConcept C170493617 @default.
• W2321822925 hasConcept C184235292 @default.
• W2321822925 hasConcept C185592680 @default.
• W2321822925 hasConcept C190283241 @default.
• W2321822925 hasConcept C195794163 @default.
• W2321822925 hasConcept C2776991684 @default.
• W2321822925 hasConcept C2778128677 @default.
• W2321822925 hasConcept C2778938600 @default.
• W2321822925 hasConcept C2779276759 @default.
• W2321822925 hasConcept C2780967304 @default.
• W2321822925 hasConcept C3675279 @default.
• W2321822925 hasConcept C55493867 @default.
• W2321822925 hasConcept C62478195 @default.
• W2321822925 hasConcept C67907053 @default.
• W2321822925 hasConcept C86803240 @default.
• W2321822925 hasConcept C95444343 @default.
• W2321822925 hasConcept C97029542 @default.
• W2321822925 hasConceptScore W2321822925C153911025 @default.
• W2321822925 hasConceptScore W2321822925C16587737 @default.
• W2321822925 hasConceptScore W2321822925C170493617 @default.
• W2321822925 hasConceptScore W2321822925C184235292 @default.
• W2321822925 hasConceptScore W2321822925C185592680 @default.
• W2321822925 hasConceptScore W2321822925C190283241 @default.
• W2321822925 hasConceptScore W2321822925C195794163 @default.
• W2321822925 hasConceptScore W2321822925C2776991684 @default.

• next