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- W2321828396 endingPage "10549" @default.
- W2321828396 startingPage "10542" @default.
- W2321828396 abstract "The drug delivery system based on supramolecular vesicles that were self-assembled by a novel host–guest inclusion complex between a water-soluble pillar[6]arene (WP6) and hydrophobic ferrocene derivative in water has been developed. The inclusion complexation between WP6 and ferrocene derivative in water was studied by 1H NMR, UV–vis, and fluorescence spectroscopy, which showed a high binding constant of (1.27 ± 0.42) × 105 M–1 with 1:1 binding stoichiometry. This resulting inclusion complex could self-assemble into supramolecular vesicles that displayed a significant pH-responsive behavior in aqueous solution, which were investigated by fluorescent probe technique, dynamic laser scattering, and transmission electron microscopy. Furthermore, the drug loading and in vitro drug release studies demonstrated that these supramolecular vesicles were able to encapsulate mitoxantrone (MTZ) to achieve MTZ-loaded vesicles, which particularly showed rapid MTZ release at low-pH environment. More importantly, the cellular uptake of these pH-responsive MTZ-loaded vesicles by cancer cells was observed by living cell imaging techniques, and their cytotoxicity assay indicated that unloaded vesicles had low toxicity to normal cells, which could dramatically reduce the toxicity of MTZ upon loading of MTZ. Meanwhile, MTZ-loaded vesicles exhibited comparable anticancer activity in vitro as free MTZ to cancer cells under examined conditions. This study suggests that such supramolecular vesicles have great potential as controlled drug delivery systems." @default.
- W2321828396 created "2016-06-24" @default.
- W2321828396 creator A5010656186 @default.
- W2321828396 creator A5014478407 @default.
- W2321828396 creator A5023563764 @default.
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- W2321828396 creator A5042374491 @default.
- W2321828396 creator A5060293966 @default.
- W2321828396 creator A5075285660 @default.
- W2321828396 date "2013-07-09" @default.
- W2321828396 modified "2023-10-02" @default.
- W2321828396 title "pH-Responsive Supramolecular Vesicles Based on Water-Soluble Pillar[6]arene and Ferrocene Derivative for Drug Delivery" @default.
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