Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321828539> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2321828539 abstract "Endothelial dysfunction plays a key role in the pathogenesis of diabetic vascular disease, including diabetic neuropathy (DNP). Endothelial-derived nitric oxide synthase (eNOS) gene polymorphisms affect eNOS activity and are associated with endothelial dysfunction. Studies examining association of eNOS gene polymorphism in type 2 diabetic patients (T2DM) with DNP and without DNP are lacking in Asian Indians. Thus, we investigated the association and interaction between two potentially functional single nucleotide polymorphisms (SNPs) of the eNOS gene (T-786C, G894T) and one repeat polymorphism (27VNTR) with DNP using validated PCR-RFLP assays in 1258 T2DM subjects belonging to two independent cohorts from north Indian Origin and also, we replicated our study in a 3rd independent cohort from south Indian population having T2DM. We also measured serum Nitric Oxide (NO) levels in these subjects and examined its correlation with DNP and eNOS genotypes. We observed that eNOS genotype carrying ‘aa’ genotype of 27VNTR (a/b) and eNOS haplotype C-a-G and C-a-T (allele of T-786C, 27VNTR a/b and G894T) carrying ‘a’ allele of 27VNTR (a/b) were associated with increased risk of DNP, in all the three cohorts. We also observed lower serum NO levels in T2DM subjects (both cases and controls) carrying ba+aa genotypes. Our study suggest that 27VNTR (a/b) eNOS polymorphism carrying ‘a’ allele alone and in association with T-786C and G894T eNOS polymorphism is associated with increased risk of DNP in Asian Indians T2DM patients." @default.
- W2321828539 created "2016-06-24" @default.
- W2321828539 creator A5001269893 @default.
- W2321828539 creator A5023814642 @default.
- W2321828539 creator A5052724921 @default.
- W2321828539 creator A5059162726 @default.
- W2321828539 creator A5060183060 @default.
- W2321828539 creator A5078341368 @default.
- W2321828539 date "2013-01-01" @default.
- W2321828539 modified "2023-09-25" @default.
- W2321828539 title "Endothelial Nitric Oxide Synthase Gene Polymorphism and the Risk of Diabetic Neuropathy in Asian Indian Patients with Type 2 Diabetes" @default.
- W2321828539 doi "https://doi.org/10.4172/2155-6156.1000243" @default.
- W2321828539 hasPublicationYear "2013" @default.
- W2321828539 type Work @default.
- W2321828539 sameAs 2321828539 @default.
- W2321828539 citedByCount "13" @default.
- W2321828539 countsByYear W23218285392015 @default.
- W2321828539 countsByYear W23218285392016 @default.
- W2321828539 countsByYear W23218285392018 @default.
- W2321828539 countsByYear W23218285392019 @default.
- W2321828539 countsByYear W23218285392020 @default.
- W2321828539 countsByYear W23218285392022 @default.
- W2321828539 countsByYear W23218285392023 @default.
- W2321828539 crossrefType "journal-article" @default.
- W2321828539 hasAuthorship W2321828539A5001269893 @default.
- W2321828539 hasAuthorship W2321828539A5023814642 @default.
- W2321828539 hasAuthorship W2321828539A5052724921 @default.
- W2321828539 hasAuthorship W2321828539A5059162726 @default.
- W2321828539 hasAuthorship W2321828539A5060183060 @default.
- W2321828539 hasAuthorship W2321828539A5078341368 @default.
- W2321828539 hasBestOaLocation W23218285391 @default.
- W2321828539 hasConcept C104317684 @default.
- W2321828539 hasConcept C126322002 @default.
- W2321828539 hasConcept C134018914 @default.
- W2321828539 hasConcept C135763542 @default.
- W2321828539 hasConcept C149737253 @default.
- W2321828539 hasConcept C2777180221 @default.
- W2321828539 hasConcept C2777622882 @default.
- W2321828539 hasConcept C2778326061 @default.
- W2321828539 hasConcept C2779178840 @default.
- W2321828539 hasConcept C2992676626 @default.
- W2321828539 hasConcept C519581460 @default.
- W2321828539 hasConcept C54355233 @default.
- W2321828539 hasConcept C555293320 @default.
- W2321828539 hasConcept C556039675 @default.
- W2321828539 hasConcept C60644358 @default.
- W2321828539 hasConcept C71924100 @default.
- W2321828539 hasConcept C76252995 @default.
- W2321828539 hasConcept C86803240 @default.
- W2321828539 hasConceptScore W2321828539C104317684 @default.
- W2321828539 hasConceptScore W2321828539C126322002 @default.
- W2321828539 hasConceptScore W2321828539C134018914 @default.
- W2321828539 hasConceptScore W2321828539C135763542 @default.
- W2321828539 hasConceptScore W2321828539C149737253 @default.
- W2321828539 hasConceptScore W2321828539C2777180221 @default.
- W2321828539 hasConceptScore W2321828539C2777622882 @default.
- W2321828539 hasConceptScore W2321828539C2778326061 @default.
- W2321828539 hasConceptScore W2321828539C2779178840 @default.
- W2321828539 hasConceptScore W2321828539C2992676626 @default.
- W2321828539 hasConceptScore W2321828539C519581460 @default.
- W2321828539 hasConceptScore W2321828539C54355233 @default.
- W2321828539 hasConceptScore W2321828539C555293320 @default.
- W2321828539 hasConceptScore W2321828539C556039675 @default.
- W2321828539 hasConceptScore W2321828539C60644358 @default.
- W2321828539 hasConceptScore W2321828539C71924100 @default.
- W2321828539 hasConceptScore W2321828539C76252995 @default.
- W2321828539 hasConceptScore W2321828539C86803240 @default.
- W2321828539 hasIssue "02" @default.
- W2321828539 hasLocation W23218285391 @default.
- W2321828539 hasOpenAccess W2321828539 @default.
- W2321828539 hasPrimaryLocation W23218285391 @default.
- W2321828539 hasRelatedWork W1563850031 @default.
- W2321828539 hasRelatedWork W2008087125 @default.
- W2321828539 hasRelatedWork W2054818626 @default.
- W2321828539 hasRelatedWork W2059080728 @default.
- W2321828539 hasRelatedWork W2089295326 @default.
- W2321828539 hasRelatedWork W2093911704 @default.
- W2321828539 hasRelatedWork W2163475302 @default.
- W2321828539 hasRelatedWork W2388905353 @default.
- W2321828539 hasRelatedWork W2487374649 @default.
- W2321828539 hasRelatedWork W2753682715 @default.
- W2321828539 hasVolume "04" @default.
- W2321828539 isParatext "false" @default.
- W2321828539 isRetracted "false" @default.
- W2321828539 magId "2321828539" @default.
- W2321828539 workType "article" @default.