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- W2321830004 abstract "Background: Trastuzumab treatment, both adjuvant and metastatic, has resulted in an improved survival for HER2 positive breast cancer patients. Cardiotoxicity of trastuzumab has been demonstrated in clinical trials, but predictive determinants of cardiotoxicity are lacking. We aimed to examine the incidence of cardiac events and identify potential predictive factors in African American and older women treated with trastuzumab, two cohorts that are under-represented in the trastuzumab trials.Methods: HER2 positive breast cancer patients who received trastuzumab, and were African American (cohort 1) or ≥ 55 years of age (cohort 2) were identified by a search of our breast database. Cohort 2 included only those women who received adjuvant trastuzumab since they were more likely to have been treated with an anthracycline similar to the patients on the two large adjuvant trastuzumab trials (B-31 & N9831) that identified age > 50 as a risk factor. Cardiac event was defined as any decline in left ventricular ejection fraction (LVEF) by > 10% points from baseline or drop to 10%, 16 (24%) with LVEF 10%, 9 (16%) with LVEF Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5087." @default.
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- W2321830004 date "2009-12-15" @default.
- W2321830004 modified "2023-10-01" @default.
- W2321830004 title "Cardiotoxicity of Trastuzumab Treatment in African American Women and Older Women in the Non Trial Setting." @default.
- W2321830004 doi "https://doi.org/10.1158/0008-5472.sabcs-09-5087" @default.
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