FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321833367> ?p ?o ?g. }

• W2321833367 endingPage "470" @default.
• W2321833367 startingPage "462" @default.
• W2321833367 abstract "Nuclear factor-kappaB (NF-κB), especially p65 subunit, has been associated with origin and progression of cancer as well as with the resistance to radiotherapy and chemotherapy in experimental models. The aim of the present study was to determine expression of NF-κB/p65 in tumor specimens before and after treatment of rectal cancer patients and to evaluate possible relationship between expression of NF-κB/p65 before and after (chemo)radiotherapy, other tumor characteristics and the clinical outcome. Furthermore, NF-κB/p65 was studied in relationship to pathologic response to preoperative (chemo)radiotherapy. Fifty patients with rectal cancer undergoing neoadjuvant (chemo)radiotherapy and surgery were included in the study. Pre-treatment rectal cancer specimens were obtained from diagnostic colonoscopy. Post-treatment rectal cancer specimens were obtained from surgically removed part of the rectum with the tumor. NF-κB/p65 expression was determined by immunohistochemistry and analysis was performed both in biopsies and in post-treatment tumor samples. Cytoplasmic positivity in tumor cells and nuclear positivity in lymphocytes were detected. High NF-κB/p65 positivity in pre-treatment tumor samples was significantly associated with shortened overall survival (OS). Disease-free survival (DFS) tends to be shortened as well. In post-treatment tumor samples, high NF-κB/p65 positivity was neither associated with shortened OS nor with shortened DFS. In post-treatment samples residual tumor cells deeply infiltrating the wall of the rectum with high NF-κB/p65 expression were found. The cells were linked to significantly worse clinical outcome in terms of shortened OS and DFS. NF-κB/p65 positivity did not correlate with pathologic response to preoperative (chemo)radiotherapy. In conclusion, our data suggest that high level of NF-κB/p65 subunit may be associated with more aggressive features of the tumor, higher metastatic potential, and shortened overall survival, but it does not correlate with resistance to (chemo)radiotherapy. Consequently, the level of NF-κB/p65 may help to select those patients who have poor prognosis and are candidates for more intensive anticancer therapy. For these purposes both pre-treatment and post-treatment tumor samples may be used." @default.
• W2321833367 created "2016-06-24" @default.
• W2321833367 creator A5020315284 @default.
• W2321833367 creator A5031641421 @default.
• W2321833367 creator A5045488940 @default.
• W2321833367 creator A5060115847 @default.
• W2321833367 creator A5078329174 @default.
• W2321833367 creator A5087458211 @default.
• W2321833367 date "2016-01-01" @default.
• W2321833367 modified "2023-09-26" @default.
• W2321833367 title "NF-κB/p65 expression before and after treatment in rectal cancer patients undergoing neoadjuvant (chemo)radiotherapy and surgery: prognostic marker for disease progression and survival" @default.
• W2321833367 doi "https://doi.org/10.4149/317_151013n525" @default.
• W2321833367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26952512" @default.
• W2321833367 hasPublicationYear "2016" @default.
• W2321833367 type Work @default.
• W2321833367 sameAs 2321833367 @default.
• W2321833367 citedByCount "10" @default.
• W2321833367 countsByYear W23218333672016 @default.
• W2321833367 countsByYear W23218333672017 @default.
• W2321833367 countsByYear W23218333672018 @default.
• W2321833367 countsByYear W23218333672019 @default.
• W2321833367 countsByYear W23218333672020 @default.
• W2321833367 countsByYear W23218333672021 @default.
• W2321833367 countsByYear W23218333672022 @default.
• W2321833367 crossrefType "journal-article" @default.
• W2321833367 hasAuthorship W2321833367A5020315284 @default.
• W2321833367 hasAuthorship W2321833367A5031641421 @default.
• W2321833367 hasAuthorship W2321833367A5045488940 @default.
• W2321833367 hasAuthorship W2321833367A5060115847 @default.
• W2321833367 hasAuthorship W2321833367A5078329174 @default.
• W2321833367 hasAuthorship W2321833367A5087458211 @default.
• W2321833367 hasBestOaLocation W23218333671 @default.
• W2321833367 hasConcept C121608353 @default.
• W2321833367 hasConcept C126322002 @default.
• W2321833367 hasConcept C142724271 @default.
• W2321833367 hasConcept C143998085 @default.
• W2321833367 hasConcept C204232928 @default.
• W2321833367 hasConcept C2776694085 @default.
• W2321833367 hasConcept C2778292576 @default.
• W2321833367 hasConcept C2778424827 @default.
• W2321833367 hasConcept C2781074409 @default.
• W2321833367 hasConcept C509974204 @default.
• W2321833367 hasConcept C526805850 @default.
• W2321833367 hasConcept C530470458 @default.
• W2321833367 hasConcept C71924100 @default.
• W2321833367 hasConceptScore W2321833367C121608353 @default.
• W2321833367 hasConceptScore W2321833367C126322002 @default.
• W2321833367 hasConceptScore W2321833367C142724271 @default.
• W2321833367 hasConceptScore W2321833367C143998085 @default.
• W2321833367 hasConceptScore W2321833367C204232928 @default.
• W2321833367 hasConceptScore W2321833367C2776694085 @default.
• W2321833367 hasConceptScore W2321833367C2778292576 @default.
• W2321833367 hasConceptScore W2321833367C2778424827 @default.
• W2321833367 hasConceptScore W2321833367C2781074409 @default.
• W2321833367 hasConceptScore W2321833367C509974204 @default.
• W2321833367 hasConceptScore W2321833367C526805850 @default.
• W2321833367 hasConceptScore W2321833367C530470458 @default.
• W2321833367 hasConceptScore W2321833367C71924100 @default.
• W2321833367 hasIssue "03" @default.
• W2321833367 hasLocation W23218333671 @default.
• W2321833367 hasLocation W23218333672 @default.
• W2321833367 hasOpenAccess W2321833367 @default.
• W2321833367 hasPrimaryLocation W23218333671 @default.
• W2321833367 hasRelatedWork W2032042555 @default.
• W2321833367 hasRelatedWork W2150621467 @default.
• W2321833367 hasRelatedWork W2404042595 @default.
• W2321833367 hasRelatedWork W2769770852 @default.
• W2321833367 hasRelatedWork W3003904233 @default.
• W2321833367 hasRelatedWork W3021135223 @default.
• W2321833367 hasRelatedWork W3029180858 @default.
• W2321833367 hasRelatedWork W3083293888 @default.
• W2321833367 hasRelatedWork W4229076162 @default.
• W2321833367 hasRelatedWork W4312640542 @default.
• W2321833367 hasVolume "63" @default.
• W2321833367 isParatext "false" @default.
• W2321833367 isRetracted "false" @default.
• W2321833367 magId "2321833367" @default.
• W2321833367 workType "article" @default.