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- W2321838229 abstract "Bovine papillomavirus (BPV) types 1 and 2 play an important role in the pathogenesis of equine sarcoids (ES), the most common cutaneous tumour affecting horses. MicroRNAs (miRNAs), small non-coding RNAs that regulate essential biological and cellular processes, have been found dysregulated in a wide range of tumours. The aim of this study was to identify miRNAs associated with ES. Differential expression of miRNAs was assessed in control equine fibroblasts (EqPalFs) and EqPalFs transformed with the BPV-1 genome (S6-2 cells). Using a commercially available miRNA microarray, 492 mature miRNAs were interrogated. In total, 206 mature miRNAs were differentially expressed in EqPalFs compared with S6-2 cells. Aberrant expression of these miRNAs in S6-2 cells can be attributed to the presence of BPV-1 genomes. Furthermore, we confirm the presence of 124 miRNAs previously computationally predicted in the horse. Our data supports the involvement of miRNAs in the pathogenesis of ES." @default.
- W2321838229 created "2016-06-24" @default.
- W2321838229 creator A5059915571 @default.
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- W2321838229 creator A5086795860 @default.
- W2321838229 creator A5089492000 @default.
- W2321838229 creator A5089634063 @default.
- W2321838229 date "2016-04-04" @default.
- W2321838229 modified "2023-09-27" @default.
- W2321838229 title "Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells" @default.
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- W2321838229 doi "https://doi.org/10.1111/vco.12216" @default.
- W2321838229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27039895" @default.
- W2321838229 hasPublicationYear "2016" @default.
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