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• W2321841011 abstract "Objectives: To compare neutralizing antibody titres against verotoxin ( vt )- 1 and vt-2 between children with uncomplicated hemorrhagic colitis ( hc ) and those with classic hemolytic uremic syndrome ( hus ). vt antibody titres were also compared in children with hc who received trimethoprim-sulfamethoxazole with those who did not. Design: Prospective study. Setting: Tertiary pediatric hospital. Population Studied: Children with hc (n=41) or classic hus (n=12). Interventions: Serum antibodies against vt-1 and vt-2 were determined by quantitative neutralization. Main Results: Antibodies were detected in 40% (21 of 53) of serum samples for vt-1 and in 100% (53 of 53) of samples for vt-2 . A positive immune response, defined as a fourfold increase in vt antibody titres or as a single titre of 1/64 or greater, was found in 0% (0 of 12) of patients with hus compared with 7% (three of 41) of those with hc for vt-1 (P=0.4); and in 17% (two of 12) of patients with hus compared with 22% (nine of 41) of those with hc for vt-2 (P=0.3). The rate of seroconversion against either vt-1 or vt-2 was comparable in treated and untreated patients with uncomplicated hc . Conclusions: There was no evidence that neutralizing antibody levels against vt-1 or vt-2 in classic hus or after antibiotic therapy are substantially different from those in patients with uncomplicated hc ." @default.
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• W2321841011 date "1995-01-01" @default.
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• W2321841011 title "Immune Response to Verotoxin 1 and 2 in Children withEscherichia ColiO157:H7 Hemorrhagic Colitis and Classic Hemolytic Uremic Syndrome" @default.
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• W2321841011 doi "https://doi.org/10.1155/1995/825478" @default.
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