FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321845949> ?p ?o ?g. }

• W2321845949 endingPage "661" @default.
• W2321845949 startingPage "654" @default.
• W2321845949 abstract "Desethylamiodarone (DEA) is the major metabolite of amiodarone and has similar electrophysiologic effects with prolongation of the repolarization that is reversed by thyroid hormone (T3). Some of the electrophysiologic effects are probably due to antagonism of T3 at the receptor level. Such effects of T3 are mediated by modulation of gene transcription. The aim of this study was to investigate whether cycloheximide (Cy), an inhibitor of protein synthesis, and actinomycin D (ActD), a RNA-synthesis inhibitor, block DEA-induced prolongation of the repolarization and whether DEA takes part in the autoregulation of the nuclear thyroid hormone-receptor subtypes (ThR). Corrected monophasic action potentials (MAPc) and QTc were measured in Langendorff-perfused guinea pig hearts for 1 h. The hearts were continuously perfused with (a) vehicle, (b) 7.5 microM Cy, (c) 5 microM DEA, (d) 5 microM DEA + 7.5 microM Cy, (e) 1 microM T3, (f) 5 microM DEA + 1 microM T3, (g) 1.5 microM ActD, and (h) ActD + DEA. A potassium channel blocker with class III antiarrhythmic effects, 0.5 microM almokalant, was used as a control, separately and together with Cy. Western blot analysis for the ThR subtypes alpha, beta1, and beta2 was performed on vehicle- and DEA-treated hearts. DEA increased MAPc by 19% (p < 0.0005) and QTc by 18% (p < 0.0005). There was no effect on MAPc or QTc when Cy, ActD, or T3 was added with DEA. Almokalant increased MAPc by 14% (p < 0.005) and QTc by 13% (p < 0.0005). When Cy was present, almokalant still induced a similar prolongation of MAPc by 14% (p < 0.005) and QTc by 17% (p < 0.0005). Western blot analysis revealed no change in the expression of the ThR protein. In conclusion, the prolongation of the cardiac repolarization by DEA, but not almokalant, can be totally blocked by Cy and ActD. This indicates that the class III action of DEA is at least in part dependent on transcription rather than a direct effect on cell-membrane channels or receptors. The action of DEA could be reversed by T3, indicating an antagonism between DEA and T3. These results suggest a new antiarrhythmic mechanism dependent on gene expression." @default.
• W2321845949 created "2016-06-24" @default.
• W2321845949 creator A5002207055 @default.
• W2321845949 creator A5039012428 @default.
• W2321845949 creator A5048843665 @default.
• W2321845949 creator A5055996027 @default.
• W2321845949 date "1998-10-01" @default.
• W2321845949 modified "2023-10-03" @default.
• W2321845949 title "Desethylamiodarone Prolongation of Cardiac Repolarization is Dependent on Gene Expression: A Novel Antiarrhythmic Mechanism" @default.
• W2321845949 cites W1971396955 @default.
• W2321845949 cites W1975544435 @default.
• W2321845949 cites W1985847958 @default.
• W2321845949 cites W1985881299 @default.
• W2321845949 cites W1990331323 @default.
• W2321845949 cites W2001862759 @default.
• W2321845949 cites W2006013913 @default.
• W2321845949 cites W2008568122 @default.
• W2321845949 cites W2013905016 @default.
• W2321845949 cites W2027971089 @default.
• W2321845949 cites W2028900561 @default.
• W2321845949 cites W2030610625 @default.
• W2321845949 cites W2041247039 @default.
• W2321845949 cites W2047696093 @default.
• W2321845949 cites W2053024322 @default.
• W2321845949 cites W2054551718 @default.
• W2321845949 cites W2058036052 @default.
• W2321845949 cites W2072298555 @default.
• W2321845949 cites W2074059408 @default.
• W2321845949 cites W2075404360 @default.
• W2321845949 cites W2075861678 @default.
• W2321845949 cites W2076463847 @default.
• W2321845949 cites W2077865259 @default.
• W2321845949 cites W2079017227 @default.
• W2321845949 cites W2088706314 @default.
• W2321845949 cites W2089724698 @default.
• W2321845949 cites W2110243945 @default.
• W2321845949 cites W2125158935 @default.
• W2321845949 cites W2165293597 @default.
• W2321845949 cites W2414021171 @default.
• W2321845949 cites W2991851951 @default.
• W2321845949 cites W4237657648 @default.
• W2321845949 cites W4246165930 @default.
• W2321845949 doi "https://doi.org/10.1097/00005344-199810000-00020" @default.
• W2321845949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9781936" @default.
• W2321845949 hasPublicationYear "1998" @default.
• W2321845949 type Work @default.
• W2321845949 sameAs 2321845949 @default.
• W2321845949 citedByCount "17" @default.
• W2321845949 countsByYear W23218459492015 @default.
• W2321845949 countsByYear W23218459492018 @default.
• W2321845949 countsByYear W23218459492020 @default.
• W2321845949 crossrefType "journal-article" @default.
• W2321845949 hasAuthorship W2321845949A5002207055 @default.
• W2321845949 hasAuthorship W2321845949A5039012428 @default.
• W2321845949 hasAuthorship W2321845949A5048843665 @default.
• W2321845949 hasAuthorship W2321845949A5055996027 @default.
• W2321845949 hasBestOaLocation W23218459491 @default.
• W2321845949 hasConcept C118441451 @default.
• W2321845949 hasConcept C126322002 @default.
• W2321845949 hasConcept C134018914 @default.
• W2321845949 hasConcept C146403970 @default.
• W2321845949 hasConcept C153911025 @default.
• W2321845949 hasConcept C185263204 @default.
• W2321845949 hasConcept C185592680 @default.
• W2321845949 hasConcept C2778094803 @default.
• W2321845949 hasConcept C2778128677 @default.
• W2321845949 hasConcept C2778131192 @default.
• W2321845949 hasConcept C2779161974 @default.
• W2321845949 hasConcept C2780074459 @default.
• W2321845949 hasConcept C3675279 @default.
• W2321845949 hasConcept C71924100 @default.
• W2321845949 hasConcept C86803240 @default.
• W2321845949 hasConcept C98274493 @default.
• W2321845949 hasConceptScore W2321845949C118441451 @default.
• W2321845949 hasConceptScore W2321845949C126322002 @default.
• W2321845949 hasConceptScore W2321845949C134018914 @default.
• W2321845949 hasConceptScore W2321845949C146403970 @default.
• W2321845949 hasConceptScore W2321845949C153911025 @default.
• W2321845949 hasConceptScore W2321845949C185263204 @default.
• W2321845949 hasConceptScore W2321845949C185592680 @default.
• W2321845949 hasConceptScore W2321845949C2778094803 @default.
• W2321845949 hasConceptScore W2321845949C2778128677 @default.
• W2321845949 hasConceptScore W2321845949C2778131192 @default.
• W2321845949 hasConceptScore W2321845949C2779161974 @default.
• W2321845949 hasConceptScore W2321845949C2780074459 @default.
• W2321845949 hasConceptScore W2321845949C3675279 @default.
• W2321845949 hasConceptScore W2321845949C71924100 @default.
• W2321845949 hasConceptScore W2321845949C86803240 @default.
• W2321845949 hasConceptScore W2321845949C98274493 @default.
• W2321845949 hasIssue "4" @default.
• W2321845949 hasLocation W23218459491 @default.
• W2321845949 hasLocation W23218459492 @default.
• W2321845949 hasLocation W23218459493 @default.
• W2321845949 hasOpenAccess W2321845949 @default.
• W2321845949 hasPrimaryLocation W23218459491 @default.
• W2321845949 hasRelatedWork W1963072091 @default.
• W2321845949 hasRelatedWork W1994013812 @default.
• W2321845949 hasRelatedWork W2067846214 @default.

• next