Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321846304> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2321846304 abstract "HCV persistence results from inefficient innate and adaptive immune responses. We investigated whether an induction approach (IA) with natural (n) IFN-beta followed by Peg IFN-alpha and ribavirin (Standard of Care; SOC) (novel combination treatment; NCT) increased the virologic response and restored innate and adaptive immune responses in chronic hepatitis C (CHC) patients with HCV genotype 1b and a high viral load. Seven CHC patients were treated with NCT. NCT overcame viral escape and breakthrough, resulting in persistent viral clearance. Early virologic responders (EAVR, n=5) with undetectable HCVRNA before the end of IA showed a sustained virologic response (SVR). Late VR (LAVR, n=2) with undetectable HCVRNA after the end of IA showed a transient VR. IL-15 was increased at the end of IA in both EAVR and LAVR. CXCL-8, CXCL-10, CCL-4, and CCL-11 levels were significantly decreased (p<0.05) in EAVR, but were not in LAVR during NCT. IL-12 increased significantly (p<0.05) and CXCL-8 decreased significantly (p<0.05) after the end of NCT in EAVR, but did not in LAVR. The present study suggested that the initial early virologic clearance induced by CPIT before the use of SOC induced the restoration of DC function and improvements in the activation of NK cells, as indicated by the up-regulation of IL-12 and IL-15 and down-regulation of CXCL-8, CXCL-10, CCL-4, CCL-11. Early virologic clearance by IA with nIFN-beta induced the restoration of innate immune responses linked to adaptive immune responses, which resulted in SVR. NCT (n=8) achieved a higher SVR rate than that of SOC (n=8) in difficultto-treat CHC patients. The results showed the safety of the nIFN-beta treatment and supported the use of nIFN-beta as a safe and alternative option. NCT is more effective and have less adverse effects than SOC in difficult-to-treat CHC patients with genotype 1b and a high viral load" @default.
- W2321846304 created "2016-06-24" @default.
- W2321846304 creator A5014285792 @default.
- W2321846304 creator A5019370527 @default.
- W2321846304 creator A5027472824 @default.
- W2321846304 creator A5044789217 @default.
- W2321846304 creator A5072577492 @default.
- W2321846304 creator A5088114847 @default.
- W2321846304 creator A5090155458 @default.
- W2321846304 date "2014-01-01" @default.
- W2321846304 modified "2023-09-27" @default.
- W2321846304 title "Restoration of Innate Immune Responses may be a Novel Therapeutic Strategy for Treatment of Chronic Hepatitis C Virus Infection" @default.
- W2321846304 doi "https://doi.org/10.4172/0974-8369.1000196" @default.
- W2321846304 hasPublicationYear "2014" @default.
- W2321846304 type Work @default.
- W2321846304 sameAs 2321846304 @default.
- W2321846304 citedByCount "0" @default.
- W2321846304 crossrefType "journal-article" @default.
- W2321846304 hasAuthorship W2321846304A5014285792 @default.
- W2321846304 hasAuthorship W2321846304A5019370527 @default.
- W2321846304 hasAuthorship W2321846304A5027472824 @default.
- W2321846304 hasAuthorship W2321846304A5044789217 @default.
- W2321846304 hasAuthorship W2321846304A5072577492 @default.
- W2321846304 hasAuthorship W2321846304A5088114847 @default.
- W2321846304 hasAuthorship W2321846304A5090155458 @default.
- W2321846304 hasConcept C136449434 @default.
- W2321846304 hasConcept C142462285 @default.
- W2321846304 hasConcept C193419808 @default.
- W2321846304 hasConcept C203014093 @default.
- W2321846304 hasConcept C2522874641 @default.
- W2321846304 hasConcept C2776408679 @default.
- W2321846304 hasConcept C2780040827 @default.
- W2321846304 hasConcept C71924100 @default.
- W2321846304 hasConcept C8891405 @default.
- W2321846304 hasConceptScore W2321846304C136449434 @default.
- W2321846304 hasConceptScore W2321846304C142462285 @default.
- W2321846304 hasConceptScore W2321846304C193419808 @default.
- W2321846304 hasConceptScore W2321846304C203014093 @default.
- W2321846304 hasConceptScore W2321846304C2522874641 @default.
- W2321846304 hasConceptScore W2321846304C2776408679 @default.
- W2321846304 hasConceptScore W2321846304C2780040827 @default.
- W2321846304 hasConceptScore W2321846304C71924100 @default.
- W2321846304 hasConceptScore W2321846304C8891405 @default.
- W2321846304 hasLocation W23218463041 @default.
- W2321846304 hasOpenAccess W2321846304 @default.
- W2321846304 hasPrimaryLocation W23218463041 @default.
- W2321846304 hasRelatedWork W1570852897 @default.
- W2321846304 hasRelatedWork W1953049057 @default.
- W2321846304 hasRelatedWork W1994810155 @default.
- W2321846304 hasRelatedWork W2000668130 @default.
- W2321846304 hasRelatedWork W2006597120 @default.
- W2321846304 hasRelatedWork W2023400145 @default.
- W2321846304 hasRelatedWork W2039363616 @default.
- W2321846304 hasRelatedWork W2044276375 @default.
- W2321846304 hasRelatedWork W2065241925 @default.
- W2321846304 hasRelatedWork W2076050031 @default.
- W2321846304 hasRelatedWork W2077308846 @default.
- W2321846304 hasRelatedWork W2096410933 @default.
- W2321846304 hasRelatedWork W2108131059 @default.
- W2321846304 hasRelatedWork W2130576335 @default.
- W2321846304 hasRelatedWork W2142663950 @default.
- W2321846304 hasRelatedWork W2150164306 @default.
- W2321846304 hasRelatedWork W2182769974 @default.
- W2321846304 hasRelatedWork W2295481881 @default.
- W2321846304 hasRelatedWork W2589875234 @default.
- W2321846304 hasRelatedWork W2746090412 @default.
- W2321846304 isParatext "false" @default.
- W2321846304 isRetracted "false" @default.
- W2321846304 magId "2321846304" @default.
- W2321846304 workType "article" @default.