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• W2321848379 abstract "To evaluate the expression of CD335 (NKp46), an activation receptor that is selectively expressed on natural killer (NK) cells.We assessed CD335's potential utility as a diagnostic marker in 657 cases by flow cytometry and 410 cases by immunohistochemistry.We observed that CD335 was highly specific for NK cells in nonneoplastic tissues. Moreover, 61 (90%) of 68 of NK cell neoplasms demonstrated CD335 expression, whereas B-cell, myelomonocytic, and plasma cell neoplasms lacked expression. Notably, 16 (20%) of 82 mature T-cell neoplasms, particularly T-cell large granular lymphocytic leukemia, mycosis fungoides, and ALK+ anaplastic large cell lymphoma, aberrantly expressed CD335.Collectively, these data support the diagnostic utility of CD335 in evaluating hematopoietic malignancies and suggest that CD335 could be a useful target for selective immunotherapy in patients with mature NK and T-cell neoplasms." @default.
• W2321848379 created "2016-06-24" @default.
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• W2321848379 date "2013-12-01" @default.
• W2321848379 modified "2023-10-06" @default.
• W2321848379 title "Expression of the Activating Receptor, NKp46 (CD335), in Human Natural Killer and T-Cell Neoplasia" @default.
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• W2321848379 doi "https://doi.org/10.1309/ajcpwgg69mczowmm" @default.
• W2321848379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24225754" @default.
• W2321848379 hasPublicationYear "2013" @default.
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