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- W2321860949 abstract "spectrometry (LC-MS/MS) method in samples collected from patients with ulcerative colitis (UC) treated with oral PD. Methods: In a single-center, observational, prospective, registered study, 20 patients both sexes, aged between 18 and 70 years, with acute relapse of UC were treated with a standard scheme of oral PD. All patients had extension of the disease above the rectum and indication for systemic corticosteroid treatment. PD was administered starting at a dose of 40mg once a day for 2 weeks. At a stable daily dose of 30mg in the last two weeks, venous blood samples for cortisol levels measurement were drawn in the morning in fasting conditions, at a 24 hour distance from last PD dose. From each sample one aliquot (200 uL of plasma from EDTA-treated blood) was used to determine circulating cortisol by LC-MS/MS assay, and one aliquot (about 1.5mL of serum from untreated blood) was used to determine circulating cortisol by ECLIA assay. Results: Median (min max) blood cortisol levels with ECLIA method were 54.1 (17.7 739.7) nmol/L, while with LC-MS/MS assay were 32.1 (14.0 439.5) nmol/L. The median (min max) of the within-patient differences between the two methods, was 23.2 ( 0.9 363.5) nmol/L reflecting higher cortisol levels measured with the ECLIA method. The estimated geometric mean ratio between methods, based on differences of log transformed data, was 1.85 (95%CI 2.39 1.43) considering all data or 1.58 (95%CI 2.30 1.09) considering only data above the limit of quantification (n = 12). The 95% confidence intervals of the geometric mean ratio between methods confirm a statistically significant difference. Conclusions: Data obtained with the ECLIA method are higher than the ones measured by LC-MS/MS, indicating overestimation of cortisol levels in patients treated with PD. We conclude that the cortisol suppression in the presence of PD should not be assessed by ECLIA method." @default.
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- W2321860949 date "2013-02-01" @default.
- W2321860949 modified "2023-09-22" @default.
- W2321860949 title "P555 Conservative approach results in lower colectomy rates in patients with severe ulcerative colitis – data from 70 patients with S3 in the ICURE study" @default.
- W2321860949 doi "https://doi.org/10.1016/s1873-9946(13)60576-0" @default.
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