FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321870572> ?p ?o ?g. }

• W2321870572 endingPage "531" @default.
• W2321870572 startingPage "513" @default.
• W2321870572 abstract "Absorption, distribution, metabolism, and excretion (ADME) studies are an integral part of the comprehensive safety evaluation of a new molecular entity, and they represent a standard suite of studies included in the registration package for all new small molecule drugs. In vivo studies in preclinical toxicology species and humans using radiolabeled ((3)H or (14)C) compound provide quantitative assessments of overall routes of excretion of drug-related material, pharmacokinetics of total drug-derived radioactivity in circulation, relative to parent compound and quantitation, and characterization of metabolites in excreta and circulation. These data serve as the starting point for metabolite in safety testing (MIST). These studies involve the administration of a radiolabeled drug to laboratory animals and humans followed by a quantitative collection of excreta and blood. Using appropriate plasma-pooling strategies, these studies could allow for modeling the metabolite exposure at the steady state. Information from the radiolabeled human study is used to design clinical drug-drug interaction (DDI) studies and to obtain a waiver for bioequivalence studies. This article describes the various aspects of conducting ADME studies and the use of radiolabeled analogues of drug candidates to investigate their metabolism and how to compare the exposures of metabolites in humans and toxicology species." @default.
• W2321870572 created "2016-06-24" @default.
• W2321870572 creator A5052048499 @default.
• W2321870572 creator A5075879261 @default.
• W2321870572 creator A5080872900 @default.
• W2321870572 date "2012-02-21" @default.
• W2321870572 modified "2023-10-16" @default.
• W2321870572 title "Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies in Drug Development: Why, When, and How?" @default.
• W2321870572 cites W1492127548 @default.
• W2321870572 cites W1499810038 @default.
• W2321870572 cites W1911522785 @default.
• W2321870572 cites W1966451644 @default.
• W2321870572 cites W1976169212 @default.
• W2321870572 cites W1982432565 @default.
• W2321870572 cites W1987144475 @default.
• W2321870572 cites W1988399857 @default.
• W2321870572 cites W1988733714 @default.
• W2321870572 cites W1991796046 @default.
• W2321870572 cites W1991942317 @default.
• W2321870572 cites W1992635584 @default.
• W2321870572 cites W1996935441 @default.
• W2321870572 cites W1997548481 @default.
• W2321870572 cites W1998414912 @default.
• W2321870572 cites W2000379995 @default.
• W2321870572 cites W2002335949 @default.
• W2321870572 cites W2004170415 @default.
• W2321870572 cites W2007541166 @default.
• W2321870572 cites W2012712901 @default.
• W2321870572 cites W2015185599 @default.
• W2321870572 cites W2021213249 @default.
• W2321870572 cites W2021420134 @default.
• W2321870572 cites W2022536452 @default.
• W2321870572 cites W2027179985 @default.
• W2321870572 cites W2033085346 @default.
• W2321870572 cites W2033602954 @default.
• W2321870572 cites W2041738960 @default.
• W2321870572 cites W2042881099 @default.
• W2321870572 cites W2044615220 @default.
• W2321870572 cites W2045337416 @default.
• W2321870572 cites W2050246204 @default.
• W2321870572 cites W2053756423 @default.
• W2321870572 cites W2062918215 @default.
• W2321870572 cites W2066625085 @default.
• W2321870572 cites W2067949274 @default.
• W2321870572 cites W2071213914 @default.
• W2321870572 cites W2076278755 @default.
• W2321870572 cites W2091707904 @default.
• W2321870572 cites W2091863056 @default.
• W2321870572 cites W2093883044 @default.
• W2321870572 cites W2096565553 @default.
• W2321870572 cites W2098841791 @default.
• W2321870572 cites W2098971041 @default.
• W2321870572 cites W2101016189 @default.
• W2321870572 cites W2101627988 @default.
• W2321870572 cites W2103762975 @default.
• W2321870572 cites W2104238162 @default.
• W2321870572 cites W2104382575 @default.
• W2321870572 cites W2109128239 @default.
• W2321870572 cites W2110568053 @default.
• W2321870572 cites W2111682379 @default.
• W2321870572 cites W2115568308 @default.
• W2321870572 cites W2116459155 @default.
• W2321870572 cites W2119622751 @default.
• W2321870572 cites W2120931971 @default.
• W2321870572 cites W2123680154 @default.
• W2321870572 cites W2123959929 @default.
• W2321870572 cites W2126901834 @default.
• W2321870572 cites W2127497390 @default.
• W2321870572 cites W2127911111 @default.
• W2321870572 cites W2128239100 @default.
• W2321870572 cites W2133728660 @default.
• W2321870572 cites W2133849435 @default.
• W2321870572 cites W2135605706 @default.
• W2321870572 cites W2135758343 @default.
• W2321870572 cites W2135772015 @default.
• W2321870572 cites W2139176209 @default.
• W2321870572 cites W2139683082 @default.
• W2321870572 cites W2142474058 @default.
• W2321870572 cites W2145797763 @default.
• W2321870572 cites W2149768137 @default.
• W2321870572 cites W2152798073 @default.
• W2321870572 cites W2153867652 @default.
• W2321870572 cites W2155854765 @default.
• W2321870572 cites W2156071438 @default.
• W2321870572 cites W2156214908 @default.
• W2321870572 cites W2157001239 @default.
• W2321870572 cites W2158891667 @default.
• W2321870572 cites W2163453478 @default.
• W2321870572 cites W2164971368 @default.
• W2321870572 cites W2165447838 @default.
• W2321870572 cites W2167564899 @default.
• W2321870572 cites W2167773607 @default.
• W2321870572 cites W2168239564 @default.
• W2321870572 cites W2168938059 @default.
• W2321870572 cites W2170437441 @default.
• W2321870572 cites W2185767923 @default.
• W2321870572 cites W2323918948 @default.
• W2321870572 cites W2325193637 @default.

• next