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- W2321872168 abstract "We present a 27-year-old male nondiabetic acromegalic patient who suffered pituitary apoplexy after a sequential pituitary stimulating test (TRH/ GnRH). He was treated with dexamethasone, 16 mg/day, which was progressively reduced from the third day reaching 0.5 mg/day on the 11th day after apoplexy. On the sixth day after the acute episode, he developed hyperglycemia with polyuria and polydipsia requiring up to 940 units a day of regular human insulin by continuous venous infusion on the ninth day after the apoplexy. At this time, the patient was receiving low dose of dexamethasone. Insulin requirements then progressively decreased, and 14 days after the acute event blood sugar levels were normal without insulin. In the face of severe insulin resistance during low dose of dexamethasone therapy, other factors causing insulin resistance were considered: anti-insulin antibodies and circulating cytokine tumor necrosis factor (TNF) levels. There was a good correlation between TNF levels and blood glucose. We discuss the possible influence of high levels of TNF in the pathogenesis of insulin resistance." @default.
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- W2321872168 date "2001-09-01" @default.
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- W2321872168 title "Insulin Resistance Associated to High Levels of Tumor Necrosis Factor (TNF) During Pituitary Apoplexy Induced by a Pituitary Stimulating Test in an Acromegalic Patient" @default.
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- W2321872168 doi "https://doi.org/10.1097/00019616-200109000-00012" @default.
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