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- W2321875206 abstract "A model is presented for determining the time when an active pharmaceutical ingredient in tablets/powders will remain within its specification limits during an in-use period; that is, when a heat-induction sealed bottle is opened for fixed time periods and where tablets are removed at fixed time points. This model combines the Accelerated Stability Assessment Program to determine the impact on degradation rates of relative humidity (RH) with calculations of the RH as a function of time for the dosage forms under in-use conditions. These calculations, in a conservative approach, assume that the air inside bottles with broached heat-induction seals completely exchanges with the external environment during periods when the bottle remains open. The solid dosages are assumed to sorb water at estimable rates during these openings. When bottles are capped, the moisture vapor transmission rate can be estimated to determine the changing RH inside the bottles between opening events. The impact of silica gel desiccants can also be included in the modeling." @default.
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- W2321875206 date "2016-04-06" @default.
- W2321875206 modified "2023-10-03" @default.
- W2321875206 title "Modeling of in-use stability for tablets and powders in bottles" @default.
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- W2321875206 doi "https://doi.org/10.3109/03639045.2016.1153648" @default.
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