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- W2321877422 abstract "We analyzed RAS mutations and PAX8/PPARγ rearrangements in follicular thyroid carcinomas (FTCs) and follicular thyroid adenomas (FTAs). We also analyzed the US findings of FTCs and FTAs. Among 92 follicular thyroid neoplasms (56 FTAs and 36 FTCs) between January 2002 and May 2013, RAS mutations in 22 FTAs and 22 FTCs and PAX8/PPARγ rearrangements in 56 FTAs and 36 FTCs were analyzed. We also analyzed the US findings of FTCs and FTAs with RAS mutations. Overall, 11 of 22 FTCs (50%) and 11 of 22 FTAs (50%) harbored RAS mutations. Two FTCs and two FTAs showed two point mutations simultaneously. K-RAS codon 12–13 (n=5, 22.7%), H-RAS codon 61 (n=4, 18.2%), N-RAS codon 61 (n=3, 13.6%), and K-RAS codon 61 (n=1, 4.5%) were found in FTCs, and H-RAS codon 61 (n=5, 22.7%), N-RAS codon 61 (n=4, 18.2%), K-RAS codon 12–13 (n=3, 13.6%), and K-RAS codon 61 (n=1, 4.5%) were observed in FTAs. 4 of 56 (7.1%) FTAs and 1 of 36 (2.8%) FTCs represented PAX8/PPARγ rearrangements (p=0.6449). The simultaneous absence of a hypoechoic rim (p = 0.021), and presence of calcifications (p = 0.049), was more strongly associated with FTCs compared with FTAs. In a Korean population, K-RAS codon 12–13 was the most common RAS mutation in FTCs, whereas H-RAS codon 61 was the most frequent mutation in FTAs. PAX8/PPARγ rearrangements were identified in both FTCs and FTAs, although at a higher frequency in FTAs. The absence of a hypoechoic rim and presence of calcifications differed significantly between FTCs and FTAs." @default.
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- W2321877422 date "2015-04-01" @default.
- W2321877422 modified "2023-10-18" @default.
- W2321877422 title "2102026 Analysis of RAS Mutation and PAX8/Pparγ Rearrangements in Follicular-Derived Thyroid Neoplasms in a Korean Population: Frequency and Ultrasound Findings" @default.
- W2321877422 doi "https://doi.org/10.1016/j.ultrasmedbio.2014.12.659" @default.
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