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• W2321879858 abstract "Locomotor recovery from anoxia follows the restoration of disordered ion distributions and neuronal excitability. The time taken for locomotor recovery after 30 s anoxia (around 10 min) is longer than the time for the propagation of action potentials to be restored (less than 1 min) in Drosophila wild-type. We report here that the white (w) gene modulates the timing of locomotor recovery. Wild-type flies displayed fast and consistent recovery of locomotion from anoxia, whereas mutants of w showed significantly delayed recovery. Genetic analysis including serial backcrossing revealed a strong association between the w locus and the timing of locomotor recovery, and haplo-insufficient function of w+ in promoting fast locomotor recovery. The locomotor recovery phenotype was independent of classic eye pigmentation, although both are associated with the w gene. Introducing up to four copies of mini-white (mw+) into w1118 was insufficient to promote fast and consistent locomotor recovery. However, flies carrying w+ duplicated to Y chromosome showed wild-type-like fast locomotor recovery. Furthermore, RNAi knockdown of w in neurons but not glia delayed locomotor recovery, and specifically, knockdown of w in putative subsets of serotonin neurons was sufficient to delay the locomotor recovery. These data reveal an additional role for w in modulating the timing of locomotor recovery from anoxia." @default.
• W2321879858 created "2016-06-24" @default.
• W2321879858 creator A5001965294 @default.
• W2321879858 creator A5058507070 @default.
• W2321879858 date "2015-11-21" @default.
• W2321879858 modified "2023-09-27" @default.
• W2321879858 title "Timing of locomotor recovery modulated by the white gene in Drosophila" @default.
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• W2321879858 doi "https://doi.org/10.1101/032490" @default.
• W2321879858 hasPublicationYear "2015" @default.
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