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• W2321885193 abstract "A series of 4H-chromenes containing various modifications in the ring B and polyalkoxy substituents in the ring E has been synthesized by Knoevenagel–Michael–hetero-Thorpe–Ziegler three-component domino reaction with the overall yield of 45–82%. The targeted molecules were evaluated in a phenotypic sea urchin embryo assay for antimitotic and microtubule destabilizing activity. The most active compounds 5{1,5} and 5{5,5} featured sesamol-derived ring B and m-methoxyphenyl or m-methoxymethylenedioxyphenyl ring E. Compounds 5{3,1}, 5{1,2}, 5{5,4}, 5{1,5}, and 5{5,5} exhibited strong cytotoxicity in the NCI60 human tumor cell line anticancer drug screen. Surprisingly, cell growth inhibition caused by these agents was more pronounced in the multidrug resistant NCI/ADR-RES cells than the parent OVCAR-8 cell line. The results suggest that polyalkoxy substited 4H-chromenes may prove to be advantageous for further design as anticancer agents." @default.
• W2321885193 created "2016-06-24" @default.
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• W2321885193 date "2012-08-06" @default.
• W2321885193 modified "2023-10-18" @default.
• W2321885193 title "Polyalkoxy Substituted 4<i>H</i>-Chromenes: Synthesis by Domino Reaction and Anticancer Activity" @default.
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• W2321885193 doi "https://doi.org/10.1021/co300062e" @default.
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• W2321885193 hasPublicationYear "2012" @default.
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