Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321888130> ?p ?o ?g. }
- W2321888130 endingPage "2923" @default.
- W2321888130 startingPage "2913" @default.
- W2321888130 abstract "Proteins and polypeptides are characterized by low-frequency vibrations in the terahertz regime responsible for the so-called “boson peak”. The shape and position of this peak are related to the mechanical properties of peptide chains. Amyloid fibrils are ordered macromolecular assemblies, spontaneously formed in nature, characterized by unique biological and nanomechanical properties. In this work, we investigate the effects of the amyloid state and its polymorphism on the boson peak. We used inelastic neutron scattering to probe low-frequency vibrations of the glucagon polypeptide in the native state and in two different amyloid morphologies in both dry and hydrated sample states. The data show that amyloid fibril formation and hydration state affect the softness of the polypeptide not only by changing the distribution of vibrational modes but also, and most significantly, the dissipative mechanisms of collective low-frequency vibrations provided by water–protein and protein–protein interactions. We show how the morphology of the fibril is able to tune these effects. Atomic fluctuations were also measured by elastic neutron scattering. The data confirm that any effect of protein aggregation on fluctuation amplitudes is essentially due to changes in surface exposure to hydration water. The results demonstrate the importance of protein–protein and protein–water interactions in the dynamics and mechanics of amyloid fibrils." @default.
- W2321888130 created "2016-06-24" @default.
- W2321888130 creator A5013724101 @default.
- W2321888130 creator A5023887372 @default.
- W2321888130 creator A5024210312 @default.
- W2321888130 creator A5045190166 @default.
- W2321888130 creator A5053725102 @default.
- W2321888130 creator A5054743711 @default.
- W2321888130 creator A5091296060 @default.
- W2321888130 date "2014-03-07" @default.
- W2321888130 modified "2023-10-06" @default.
- W2321888130 title "The Boson Peak of Amyloid Fibrils: Probing the Softness of Protein Aggregates by Inelastic Neutron Scattering" @default.
- W2321888130 cites W1964976698 @default.
- W2321888130 cites W1967078910 @default.
- W2321888130 cites W1967701034 @default.
- W2321888130 cites W1967733770 @default.
- W2321888130 cites W1970898345 @default.
- W2321888130 cites W1971685337 @default.
- W2321888130 cites W1978063542 @default.
- W2321888130 cites W1978718923 @default.
- W2321888130 cites W1983995204 @default.
- W2321888130 cites W1990326868 @default.
- W2321888130 cites W1990712184 @default.
- W2321888130 cites W1997944660 @default.
- W2321888130 cites W1999993645 @default.
- W2321888130 cites W2001849713 @default.
- W2321888130 cites W2002368654 @default.
- W2321888130 cites W2004098528 @default.
- W2321888130 cites W2024410237 @default.
- W2321888130 cites W2024568067 @default.
- W2321888130 cites W2024943432 @default.
- W2321888130 cites W2025607001 @default.
- W2321888130 cites W2027465889 @default.
- W2321888130 cites W2034951358 @default.
- W2321888130 cites W2035241014 @default.
- W2321888130 cites W2038559728 @default.
- W2321888130 cites W2039277928 @default.
- W2321888130 cites W2040755656 @default.
- W2321888130 cites W2042413457 @default.
- W2321888130 cites W2048950875 @default.
- W2321888130 cites W2050104778 @default.
- W2321888130 cites W2056597071 @default.
- W2321888130 cites W2058933615 @default.
- W2321888130 cites W2063627711 @default.
- W2321888130 cites W2067031014 @default.
- W2321888130 cites W2070124322 @default.
- W2321888130 cites W2071250884 @default.
- W2321888130 cites W2071837902 @default.
- W2321888130 cites W2075092972 @default.
- W2321888130 cites W2075791526 @default.
- W2321888130 cites W2082776814 @default.
- W2321888130 cites W2088370096 @default.
- W2321888130 cites W2092970261 @default.
- W2321888130 cites W2093791427 @default.
- W2321888130 cites W2095425304 @default.
- W2321888130 cites W2105525202 @default.
- W2321888130 cites W2110227826 @default.
- W2321888130 cites W2117310189 @default.
- W2321888130 cites W2119977598 @default.
- W2321888130 cites W2128879174 @default.
- W2321888130 cites W2155027540 @default.
- W2321888130 cites W2323511515 @default.
- W2321888130 cites W2326163944 @default.
- W2321888130 cites W2331263692 @default.
- W2321888130 cites W2963190379 @default.
- W2321888130 doi "https://doi.org/10.1021/jp412277y" @default.
- W2321888130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24568616" @default.
- W2321888130 hasPublicationYear "2014" @default.
- W2321888130 type Work @default.
- W2321888130 sameAs 2321888130 @default.
- W2321888130 citedByCount "6" @default.
- W2321888130 countsByYear W23218881302014 @default.
- W2321888130 countsByYear W23218881302015 @default.
- W2321888130 countsByYear W23218881302016 @default.
- W2321888130 countsByYear W23218881302019 @default.
- W2321888130 crossrefType "journal-article" @default.
- W2321888130 hasAuthorship W2321888130A5013724101 @default.
- W2321888130 hasAuthorship W2321888130A5023887372 @default.
- W2321888130 hasAuthorship W2321888130A5024210312 @default.
- W2321888130 hasAuthorship W2321888130A5045190166 @default.
- W2321888130 hasAuthorship W2321888130A5053725102 @default.
- W2321888130 hasAuthorship W2321888130A5054743711 @default.
- W2321888130 hasAuthorship W2321888130A5091296060 @default.
- W2321888130 hasConcept C104015590 @default.
- W2321888130 hasConcept C120665830 @default.
- W2321888130 hasConcept C121332964 @default.
- W2321888130 hasConcept C12554922 @default.
- W2321888130 hasConcept C142724271 @default.
- W2321888130 hasConcept C159467904 @default.
- W2321888130 hasConcept C179104552 @default.
- W2321888130 hasConcept C185592680 @default.
- W2321888130 hasConcept C191486275 @default.
- W2321888130 hasConcept C192562407 @default.
- W2321888130 hasConcept C27523624 @default.
- W2321888130 hasConcept C2777633098 @default.
- W2321888130 hasConcept C2779134260 @default.
- W2321888130 hasConcept C2994168385 @default.
- W2321888130 hasConcept C3019447875 @default.