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- W2321898561 abstract "Background IL-32, a recently described cytokine promoting pro-inflammatory cytokines such as IL-1β, IL-6, CXCL8 and TNFα, has emerged as a key component in the development of chronic inflammatory diseases such as rheumatoid arthritis. Objectives To we investigate IL-32 expression at transctipt and protein level and identify IL-32 producing cells in the salivary glands (SG) of Sjogren’s Syndrome (SS) patients. Methods IL-32 mRNA expression level was assessed by Taqman quantitative PCR in SG of SS patients and non-specific chronic sialadenitis (NSCS) as controls. Patients and control were enrolled in two different Centres. In addition, immunohistochemistry was used to assess IL-32 expression and the formation of B/T cell aggregates. Double immunofluorescence for IL-32 and CD68 was used to identify the cellular source of IL-32 in the SG. Results Expression of IL-32 correlated with the severity of inflammation and was significantly increased in SS patients compared to NSCS controls (mean±SEM; 10.3±2.1 vs 4.1±0.5, p Conclusions Here we show that IL-32 expression is significantly increased in the SG of SS patients where both ductal epithelial cells and monocyte-derived cells abundantly express this cytokine. These data strongly implicate IL-32 in the maintenance of chronic inflammation in the target organ of SS. Disclosure of Interest None Declared" @default.
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- W2321898561 date "2013-06-01" @default.
- W2321898561 modified "2023-09-26" @default.
- W2321898561 title "AB0222 Monocyte-derived IL-32 expression correlates with the level of inflammation in salivary glands of sjÖgren’s syndrome" @default.
- W2321898561 doi "https://doi.org/10.1136/annrheumdis-2012-eular.222" @default.
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