FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321899501> ?p ?o ?g. }

• W2321899501 endingPage "2365" @default.
• W2321899501 startingPage "2359" @default.
• W2321899501 abstract "The prevalence of fusidic acid (FA) resistance amongStaphylococcus aureusstrains in New Zealand (NZ) is among the highest reported globally, with a recent study describing a resistance rate of approximately 28%. Three FA-resistantS. aureusclones (ST5 MRSA, ST1 MSSA, and ST1 MRSA) have emerged over the past decade and now predominate in NZ, and in all three clones FA resistance is mediated by thefusCgene. In particular, ST5 MRSA has rapidly become the dominant MRSA clone in NZ, although the origin of FA-resistant ST5 MRSA has not been explored, and the genetic context offusCin FA-resistant NZ isolates is unknown. To better understand the rapid emergence of FA-resistantS. aureus, we used population-based comparative genomics to characterize a collection of FA-resistant and FA-susceptible isolates from NZ. FA-resistant NZ ST5 MRSA displayed minimal genetic diversity and represented a phylogenetically distinct clade within a global population model of clonal complex 5 (CC5)S. aureus In all lineages,fusCwas invariably located within staphylococcal cassette chromosome (SCC) elements, suggesting that SCC-mediated horizontal transfer is the primary mechanism offusCdissemination. The genotypic association offusCwithmecAhas important implications for the emergence of MRSA clones in populations with high usage of fusidic acid. In addition, we found thatfusCwas colocated with a recently described virulence factor (tirS) in dominant NZS. aureusclones, suggesting a fitness advantage. This study points to the likely molecular mechanisms responsible for the successful emergence and spread of FA-resistantS. aureus." @default.
• W2321899501 created "2016-06-24" @default.
• W2321899501 creator A5002105758 @default.
• W2321899501 creator A5033969972 @default.
• W2321899501 creator A5051406237 @default.
• W2321899501 creator A5058500554 @default.
• W2321899501 creator A5064702944 @default.
• W2321899501 creator A5077263916 @default.
• W2321899501 creator A5082217676 @default.
• W2321899501 creator A5088404965 @default.
• W2321899501 creator A5090054061 @default.
• W2321899501 date "2016-04-01" @default.
• W2321899501 modified "2023-10-18" @default.
• W2321899501 title "Rapid Emergence and Evolution of Staphylococcus aureus Clones Harboring <i>fusC</i> -Containing Staphylococcal Cassette Chromosome Elements" @default.
• W2321899501 cites W113427216 @default.
• W2321899501 cites W1583756835 @default.
• W2321899501 cites W1883119824 @default.
• W2321899501 cites W1974480979 @default.
• W2321899501 cites W1986374905 @default.
• W2321899501 cites W1991330646 @default.
• W2321899501 cites W2005522415 @default.
• W2321899501 cites W2022600772 @default.
• W2321899501 cites W2030063209 @default.
• W2321899501 cites W2040731143 @default.
• W2321899501 cites W2096093282 @default.
• W2321899501 cites W2107139181 @default.
• W2321899501 cites W2108051534 @default.
• W2321899501 cites W2113651812 @default.
• W2321899501 cites W2116214653 @default.
• W2321899501 cites W2120826109 @default.
• W2321899501 cites W2120902911 @default.
• W2321899501 cites W2125675160 @default.
• W2321899501 cites W2137015675 @default.
• W2321899501 cites W2143004077 @default.
• W2321899501 cites W2146370523 @default.
• W2321899501 cites W2146585047 @default.
• W2321899501 cites W2156273926 @default.
• W2321899501 cites W2157767491 @default.
• W2321899501 cites W2162052530 @default.
• W2321899501 cites W2169546186 @default.
• W2321899501 cites W2170367123 @default.
• W2321899501 doi "https://doi.org/10.1128/aac.03020-15" @default.
• W2321899501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4808225" @default.
• W2321899501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26856837" @default.
• W2321899501 hasPublicationYear "2016" @default.
• W2321899501 type Work @default.
• W2321899501 sameAs 2321899501 @default.
• W2321899501 citedByCount "40" @default.
• W2321899501 countsByYear W23218995012016 @default.
• W2321899501 countsByYear W23218995012017 @default.
• W2321899501 countsByYear W23218995012018 @default.
• W2321899501 countsByYear W23218995012019 @default.
• W2321899501 countsByYear W23218995012020 @default.
• W2321899501 countsByYear W23218995012021 @default.
• W2321899501 countsByYear W23218995012022 @default.
• W2321899501 countsByYear W23218995012023 @default.
• W2321899501 crossrefType "journal-article" @default.
• W2321899501 hasAuthorship W2321899501A5002105758 @default.
• W2321899501 hasAuthorship W2321899501A5033969972 @default.
• W2321899501 hasAuthorship W2321899501A5051406237 @default.
• W2321899501 hasAuthorship W2321899501A5058500554 @default.
• W2321899501 hasAuthorship W2321899501A5064702944 @default.
• W2321899501 hasAuthorship W2321899501A5077263916 @default.
• W2321899501 hasAuthorship W2321899501A5082217676 @default.
• W2321899501 hasAuthorship W2321899501A5088404965 @default.
• W2321899501 hasAuthorship W2321899501A5090054061 @default.
• W2321899501 hasBestOaLocation W23218995011 @default.
• W2321899501 hasConcept C104317684 @default.
• W2321899501 hasConcept C135763542 @default.
• W2321899501 hasConcept C141231307 @default.
• W2321899501 hasConcept C151730666 @default.
• W2321899501 hasConcept C157887575 @default.
• W2321899501 hasConcept C2777052132 @default.
• W2321899501 hasConcept C2777334864 @default.
• W2321899501 hasConcept C2777805791 @default.
• W2321899501 hasConcept C2779343474 @default.
• W2321899501 hasConcept C2779489039 @default.
• W2321899501 hasConcept C2780483375 @default.
• W2321899501 hasConcept C2908647359 @default.
• W2321899501 hasConcept C4918238 @default.
• W2321899501 hasConcept C523546767 @default.
• W2321899501 hasConcept C54355233 @default.
• W2321899501 hasConcept C60987743 @default.
• W2321899501 hasConcept C71924100 @default.
• W2321899501 hasConcept C81089528 @default.
• W2321899501 hasConcept C86803240 @default.
• W2321899501 hasConcept C89423630 @default.
• W2321899501 hasConcept C99454951 @default.
• W2321899501 hasConceptScore W2321899501C104317684 @default.
• W2321899501 hasConceptScore W2321899501C135763542 @default.
• W2321899501 hasConceptScore W2321899501C141231307 @default.
• W2321899501 hasConceptScore W2321899501C151730666 @default.
• W2321899501 hasConceptScore W2321899501C157887575 @default.
• W2321899501 hasConceptScore W2321899501C2777052132 @default.
• W2321899501 hasConceptScore W2321899501C2777334864 @default.
• W2321899501 hasConceptScore W2321899501C2777805791 @default.
• W2321899501 hasConceptScore W2321899501C2779343474 @default.
• W2321899501 hasConceptScore W2321899501C2779489039 @default.

• next